نتایج جستجو برای: programmed cell death 1 receptor

تعداد نتایج: 4393069  

Background: Programmed cell death protein-1 (PD-1)/PD-L1 pathway is one of the immune checkpoint pathways involved in regulation of the immune responses and suppression of anti-tumor defense. PD-1/B7-H1-blocking antibodies improve immune responses such as cytotoxic activity of CD8+/CD4+T cells and also increase mortality of tumor cells; however their use is accompanied by adverse effects in pat...

2017
Sylvain Simon Nathalie Labarriere

Inhibitory properties of PD-1 receptor engagement on activated T cells are well established in physiologic and pathological contexts. In cancer, the use of checkpoint blockade, such as anti-PD-1 antibodies, becomes progressively a reference treatment of a growing number of tumors. Nonetheless, it is also established that PD-1 expression on antigen-specific T cells reflects the functional avidit...

Journal: :Journal of immunology 2006
Christine Deppong Twyla I Juehne Michelle Hurchla Lindzy D Friend Dulari D Shah Christine M Rose Traci L Bricker Laurie P Shornick Erika C Crouch Theresa L Murphy Michael J Holtzman Kenneth M Murphy Jonathan M Green

T cell activation is regulated by coordinate interaction of the T cell Ag receptor and costimulatory signals. Although there is considerable insight into processes that regulate the initiation of inflammation, less is known about the signals that terminate immune responses. We have examined the role of the inhibitory receptors programmed death receptor-1 and B and T lymphocyte attenuator in the...

Journal: :Journal of Pakistan Medical Association 2023

Objective: To evaluate programmed death-ligand 1 immunohistochemical expression in the available variants of urinary bladder carcinoma, and to correlate its with clinicopathological features.Method: The retrospective study was conducted at Faculty Medicine, Kafrelsheikh University, Egypt, from February 2020 April 2021, comprised formalin-fixed paraffin-embedded specimens carcinoma belonging pat...

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