Research was initiated to physically characterize the mitochondrial genomes of several Meloidogyne spp. and host-races, to address questions regarding their systematics and dispersal, and to assess the possibility of developing molecular diagnostics for these nematodes. Techniques were developed for purification and rapid detection of mitochondrial DNA from root-knot nematodes. Mitochondrial DN...

Recent advances in the understanding of the molecular basis of cancer and the development of molecular diagnostics based on this knowledge have done much to progress the fields of oncology and pathology. Technological developments such as Next Generation Sequencing (NGS) and multiplex assays have made feasible the widespread adoption of molecular diagnostics for clinical use. While these develo...

The measurement uncertainty budget should combine the uncertainty of higher order references, the uncertainty of commercial system calibration, the system imprecision and individual laboratory performance in terms of variability. Here we recommend that no more than one third of the total uncertainty budget, established by appropriate analytical performance specifications, is consumed by the unc...

OBJECTIVE In this study, we determined the assay performance criteria necessary to produce acceptable results for >or=98% of neonate bilirubin samples collected by capillary heel-stick. STUDY DESIGN AND METHODS We determined serum free hemoglobin levels in 151 heel-stick serum samples to determine the hemolysis level. We then tested the effect of hemolysis on total bilirubin levels determined...

This paper presents a new approach to modeling speech spectra and pitch for text-independent speaker identification using Gaussian mixture models based on multi-space probability distribution (MSD-GMM). The MSD-GMM allows us to model continuous pitch values for voiced frames and discrete symbols representing unvoiced frames in a unified framework. Spectral and pitch features are jointly modeled...

In many laboratories, microscopy still remains the cornerstone of parasitological diagnostics and provides an epidemiological assessment parasite burden. High-quality diagnostic service includes participation in external quality assurance (EQA) scheme to help measure service. This presentation will review laboratories' performance liquid EQA programs offered by RCPAQAP. Results for different st...

neurocysticercosis, is the infection caused by the larval form of the tapeworm taenia solium. it is considered as the most common parasitic disease of the central nervous system and the most common cause of acquired epilepsy. this has primarily been a disease that remains endemic in countries with poor economy , but because of increased migration neurocysticercosis is being diagnosed more frequ...

Title of dissertation: Collinearity Diagnostics for Complex Survey Data Dan Liao Doctor of Philosophy, 2010 Dissertation directed by: Professor Richard Valliant Joint Program in Survey Methodology Survey data are often used to fit models. The values of covariates used in modeling are not controlled as they might be in an experiment. Thus, collinearity among the covariates is an inevitable probl...