نتایج جستجو برای: proapoptotic gene

تعداد نتایج: 1144687  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2010
Hera Chaudhury Mustafa Zakkar Joseph Boyle Simon Cuhlmann Kim van der Heiden Le Anh Luong Jeremy Davis Adam Platt Justin C Mason Rob Krams Dorian O Haskard Andrew R Clark Paul C Evans

OBJECTIVE Atherosclerosis is a focal disease that occurs predominantly at branches and bends of the arterial tree. Endothelial cells (EC) at atherosusceptible sites are prone to injury, which can contribute to lesion formation, whereas EC at atheroprotected sites are resistant. The c-Jun N-terminal kinase (JNK) is activated constitutively in EC at atherosusceptible sites but is inactivated at a...

2002
Christian Trautwein Suzanne M. Lohmann Helmut Drexler Kai C. Wollert Beate Fiedler Stepan Gambaryan Albert Smolenski Jörg Heineke Elke Butt

NO acting through soluble guanylyl cyclase and cGMP formation is a negative regulator of cardiomyocyte hypertrophy. Downstream targets mediating the inhibitory effects of NO/cGMP on cardiomyocyte hypertrophy have not been elucidated. In addition to its antihypertrophic effects, NO promotes apoptosis in cardiomyocytes, presumably through cGMP-independent pathways. We investigated the role of cGM...

2003
Florian Rödicker Brigitte M. Pützer

Novel therapies such as gene therapy are needed for the treatment of pancreatic carcinomas. Here we show that adenovirus-mediated p73 overexpression results in a strong induction of apoptosis, whereas the effect of p53 varies between different cell lines. In particular, p53-negative AsPC-1 cells are resistant to p53-mediated apoptosis. In these cells, only ectopically expressed p73 activates th...

Journal: :Cancer research 2003
Florian Rödicker Brigitte M Pützer

Novel therapies such as gene therapy are needed for the treatment of pancreatic carcinomas. Here we show that adenovirus-mediated p73 overexpression results in a strong induction of apoptosis, whereas the effect of p53 varies between different cell lines. In particular, p53-negative AsPC-1 cells are resistant to p53-mediated apoptosis. In these cells, only ectopically expressed p73 activates th...

2010
Rayyan A Kayal Michelle Siqueira Jazia Alblowi Jody McLean Nanarao Krothapalli Dan Faibish Thomas A Einhorn Louis C Gerstenfeld Dana T Graves

To gain insight into the effect of diabetes on fracture healing, experiments were carried out focusing on chondrocyte apoptosis during the transition from cartilage to bone. Type 1 diabetes was induced in mice by multiple low-dose streptozotocin injections, and simple transverse fractures of the tibia or femur was carried out. Large-scale transcriptional profiling and gene set enrichment analys...

Journal: :Hypertension 2002
Kai C Wollert Beate Fiedler Stepan Gambaryan Albert Smolenski Jörg Heineke Elke Butt Christian Trautwein Suzanne M Lohmann Helmut Drexler

NO acting through soluble guanylyl cyclase and cGMP formation is a negative regulator of cardiomyocyte hypertrophy. Downstream targets mediating the inhibitory effects of NO/cGMP on cardiomyocyte hypertrophy have not been elucidated. In addition to its antihypertrophic effects, NO promotes apoptosis in cardiomyocytes, presumably through cGMP-independent pathways. We investigated the role of cGM...

Journal: :Current Genomics 2008
Jürgen Eberle Amir M Hossini

Bcl-2 proteins are critical regulators of mitochondrial membrane permeability and the proapoptotic mitochondrial pathway. The family encloses pro- and antiapoptotic factors encoded by over 15 genes, which frequently give rise to alternative splice products. Antiapoptotic, proapoptotic multidomain, and proapoptotic BH3-only proteins are characterized by the presence of at least one of four Bcl-2...

Journal: :Journal of virology 2014
Amos Markus Hiba Waldman Ben-Asher Paul R Kinchington Ronald S Goldstein

Transcriptional changes following varicella-zoster virus (VZV) infection of cultured human neurons derived from embryonic stem cells were compared to those in VZV-infected human foreskin fibroblasts. Transcription of 340 neuronal genes significantly altered by VZV infection included 223 transcript changes unique to neurons. Strikingly, genes inhibiting apoptosis were upregulated in neurons, whi...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Servane Tauszig-Delamasure Li-Ying Yu Jorge Ruben Cabrera Jimena Bouzas-Rodriguez Catherine Mermet-Bouvier Catherine Guix Marie-Claire Bordeaux Urmas Arumäe Patrick Mehlen

The TrkC/NT-3 receptor/ligand pair is believed to be part of the classic neurotrophic theory claiming that neuronal death occurs by default when neurotrophic factors become limited, through loss of survival signals. Here, we show that TrkC is a dependence receptor and, as such, induces caspase-dependent apoptotic death in the absence of NT-3 in immortalized cells, a proapoptotic activity inhibi...

Journal: :Science 2000
H Li S K Kolluri J Gu M I Dawson X Cao P D Hobbs B Lin G Chen J Lu F Lin Z Xie J A Fontana J C Reed X Zhang

TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis. Mitochondrial targeting of TR3, but not its DNA binding and transactiva...

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