OBJECTIVE To analyse pharmacist intervention (PI) resulting from the implementation of the Dáder Pharmacotherapeutic Follow-Up Program (PFU). DESIGN Descriptive study of the findings from the PFU program during the first year. SETTING Community pharmacists in area of the College of Pharmacists of the Province of Cordoba (Argentina). PARTICIPANTS A total of 202 patients were included in th...

Nitazoxanide (NTZ), a drug currently being tested in human clinical trials for efficacy against chronic cryptosporidiosis, was assessed in cell culture and in two animal models. The inhibitory activity of NTZ was compared with that of paromomycin (PRM), a drug that is partially effective against Cryptosporidium parvum. A concentration of 10 microg of NTZ/ml (32 microM) consistently reduced para...

The main paradigm for practical motion planning in the last two decades is Probabilistic Road Map (PRM). We propose an alternative paradigm called Soft Subdivision Search (SSS). The SSS approach is based on two ingredients: the standard subdivision of space, coupled with soft predicates. Such predicates are conservative and convergent relative to exact predicates. This leads to a new class of r...

Cysteine (Cys) is prone to diverse post-translational modifications in proteins, including oxidation into sulfenic acid (Cys-SOH) by reactive oxygen species generated under oxidative stress. Detection of low concentrated and metastable Cys-SOH within complex biological matrices challenging due the dynamic concentration range proteins samples. Herein, visible laser-induced dissociation (LID) imp...

BACKGROUND The total protein content of urine is a good index of renal function, but its determination is unreliable. Protein dye-binding assays are simple, but they characteristically lack a uniform response to different proteins. METHODS We investigated a differential response of the Sigma Microprotein Coomassie Brilliant Blue (CBB) and Pyrogallol Red-molybdate (PRM) protein dye-binding ass...

Cells infected with dengue virus release a high proportion of immature prM-containing virions. In accordance, substantial levels of prM antibodies are found in sera of infected humans. Furthermore, it has been recently described that the rates of prM antibody responses are significantly higher in patients with secondary infection compared to those with primary infection. This suggests that imma...

During spermatogenesis in mammals, the transcripts of transition protein 1 (TP 1) and protamine 1 (Prm 1) are under translational regulation. Following their transcription in round spermatids, the mRNAs for TP 1 and Prm 1 are stored in the cytoplasm from 3-7 days before being translated towards the end of spermatogenesis. To test the hypothesis that the inactivation or activation of transcripts...

OBJECTIVE Shared decision-making and the use of decision aids are increasingly promoted in various healthcare settings. The extent of their current use and potential in rehabilitation medicine is unknown. The aim of the present study was to explore the barriers to and facilitators of shared decision-making and use of decision aids in daily practice, and to explore the perceptions of physical an...

We propose the combination of techniques that solve multiple queries for motion planning problems with single query planners in a motion planning framework that can be efficiently parallelized. In multiple query motion planning, a data structure is built during a preprocessing phase in order to quickly respond to on-line queries. Alternatively, in single query planning, there is no preprocessin...

background: although aberrant protamine (prm) ratios have been observed in infertile men, the mechanisms that implicit the uncoupling of prm1 and prm2 expression remain unclear. to uncover these mechanisms, in this observational study we have compared the prm1/prm2 mrna ratio and mrna contents of two regulatory factors of these genes. materials and methods: in this experimental study, sampling ...