In mammalian ovaries, a fixed population of primordial follicles forms during the perinatal stage and the oocytes contained within are arrested at the dictyate stage of meiotic prophase I. In the current study, we provide evidence that the level of cyclic AMP (cAMP) in oocytes regulates oocyte meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary. Our results show that...

Initiation of folliculogenesis through the induction of primordial follicle development in the ovary has an important role in determining the fertility and reproductive fitness of most mammalian species. The factors that control this critical process are largely unknown. The hypothesis tested in the current study was that kit-ligand/stem cell factor (KL) promotes the initiation and progression ...

Primordial black holes (PBHs) from the early Universe have been connected with nature of dark matter and can significantly affect cosmological history. We show that coincidence radiation density fluctuation gravitational wave signatures associated evaporation ≲109 g PBHs be used to explore obtain important hints about formation mechanisms spinning non-spinning spanning orders magnitude in mass-...

BACKGROUND C-src is an evolutionarily conserved proto-oncogene that regulates cell proliferation, differentiation and apoptosis. In our previous studies, we have reported that another proto-oncogene, c-erbB2, plays an important role in primordial follicle activation and development. We also found that c-src was expressed in mammalian ovaries, but its functions in primordial follicle activation ...

We model with numerical algorithms the dynamical processes that possibly lead to the trapping of Jupiter’s Trojans from a primordial population of planetesimals orbiting nearby a proto-Jupiter. The predictions of models based on mutual planetesimal collisions and on the mass growth of Jupiter are compared with observations. In particular, we concentrate on the distribution of the libration ampl...

Recent research has severely constrained the standard “defect” models of cosmic structure formation. Here I discuss the nature of the problems with defect models, and place this discussion in the context of the big picture of cosmic structure formation. In particular, I classify models of cosmic structure formation as either “causal” or “acausal”, and ask whether the problems with the defect mo...

The murine primordial follicle pool develops largely within 3 days after birth through germline nest breakdown and enclosure of oocytes within pregranulosa cells. The mechanisms that trigger primordial follicle formation likely are influenced by a transition from the maternal to fetal hormonal milieu at the time of birth. High levels of maternal estrogen maintain intact germline nest in fetal o...