نتایج جستجو برای: primary progressive ms

تعداد نتایج: 862134  

Journal: :Neurology - Neuroimmunology Neuroinflammation 2017

2016

Submit Manuscript | http://medcraveonline.com Abbreviations: TCR: γδT Receptor; RE: Rasmussen’s Encephalitis; CD: Cortical Dysplasia; APCs: Antigen Presenting Cells; MS: Multiple Sclerosis; BBB: Blood Brian Barrier; GBM: Glioblastoma Multiforme; MGMT: Methylguanine Methyltransferase; NK: Natural Killer; WNV: West Nile virus RR: Relapsing Remitting; PP: Primary Progressive; SP: Secondary Progres...

2016
Samar S. Ayache Moussa A. Chalah

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and represents a major cause of disability in young adults. Nowadays, the dichotomy between demyelination and neurodegeneration has been challenged, and both processes are believed to occur independently early in the disease process. 'Relapsing-remitting' MS is the most common subtype which generally shifts to a 'sec...

2011
Rosalia D'Angelo Concetta Crisafulli Carmela Rinaldi Alessia Ruggeri Aldo Amato Antonina Sidoti

Multiple sclerosis (MS) disease is carried through inflammatory and degenerative stages. Based on clinical feaures, it can be subdivided into three groups: relapsing-remitting MS, secondary progressive MS, and primary progressive MS. Multiple sclerosis has a multifactorial etiology with an interplay of genetic predisposition, environmental factors, and autoimmune inflammatory mechanism in which...

2012
Hervé Perron Raphaëlle Germi Corinne Bernard Marta Garcia-Montojo Cécile Deluen Laurent Farinelli Raphaël Faucard Francisco Veas Ilias Stefas Babs O Fabriek Jack Van-Horssen Paul Van-der-Valk Claire Gerdil Roberta Mancuso Marina Saresella Mario Clerici Sébastien Marcel Alain Creange Rosella Cavaretta Domenico Caputo Giannina Arru Patrice Morand Alois B Lang Stefano Sotgiu Klemens Ruprecht Peter Rieckmann Pablo Villoslada Michel Chofflon Jose Boucraut Jean Pelletier Hans-Peter Hartung

BACKGROUND The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family 'W' (HERV-W), induces dysimmunity and inflammation. OBJECTIVE The objective of this study was to confirm and specify the association between HERV-W/MSRV envelope (Env) expression and MS. METHODS 103 MS, 199 healthy controls (HC) and controls w...

2017
Sebastian Wurth Bettina Kuenz Gabriel Bsteh Rainer Ehling Franziska Di Pauli Harald Hegen Michael Auer Viktoria Gredler Florian Deisenhammer Markus Reindl Thomas Berger

BACKGROUND There is evidence that B cells play an important role in disease pathology of multiple sclerosis (MS). The aim of this prospective observational study was to determine the predictive value of cerebrospinal fluid (CSF) B cell subtypes in disease evolution of patients with MS. MATERIALS AND METHODS 128 patients were included between 2004 and 2012. Median follow up time was 7.9 years ...

2015
Marta Tejera-Alhambra Armanda Casrouge Clara de Andrés Ansgar Seyfferth Rocío Ramos-Medina Bárbara Alonso Janet Vega Lidia Fernández-Paredes Matthew L. Albert Silvia Sánchez-Ramón Oscar Arias-Carrion

Multiple sclerosis, the most common cause of neurological disability in young population after trauma, represents a significant public health burden. Current challenges associated with management of multiple sclerosis (MS) patients stem from the lack of biomarkers that might enable stratification of the different clinical forms of MS and thus prompt treatment for those patients with progressive...

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