Primary cutaneous lymphomas are extranodal non-Hodgkin of T- or B- cell origin, that predominantly affect older patients but have been reported in all age groups and as early the first years life. Diagnosis is challenging requires high clinical suspicion close collaboration between dermatologists, pediatric oncologists pathologists. Skin involvement children adolescents can either be primary se...

The treatment of advanced stage primary cutaneous T-cell lymphomas remains challenging. In particular, large-cell transformation of mycosis fungoides is associated with a median overall survival of two years for all stages taken together. Little is known regarding allogeneic hematopoietic stem cell transplantation in this context. We performed a multicenter retrospective analysis of 37 cases of...

Primary cutaneous lymphomas, which are diagnosed with only skin involvement, can be of B or T cell origin. Due to their varied origin as well diverse presentations, these groups have been divided further into more descriptive and representative groups. The subtypes primary marginal zone lymphoma (PCMZL), follicle center (PCFCL), diffuse large lymphoma, leg type (PCDLBCL-LT) intravascular B-cell...

Primary B-cell lymphomas of the skin are not as rare as is generally believed. They are defined as malignant B-cell proliferations presenting with cutaneous involvement alone and no evidence of extracutaneous manifestations over a period of at least six months when complete staging has been performed. The major subtypes are follicle center-cell lymphoma of the head and trunk, immunocytoma and l...

toxic T-cell phenotype. J Invest Dermatol 1997; 109: ing, T-cell-receptor gene rearrangement and electron microscopic studies. Br J Dermatol 1992; 126: 404–408. 636–640. 7. El Shabrawi-Caelen L, Cerroni L, Kerl H. The clinicopa10. Berti E, Tomasini D, Vermeer MH, Meijer CJ, Alessi E, Willemze R. Primary cutaneous CD8-positive epidermothologic spectrum of cytotoxic lymphomas of the skin. Semin C...

Primary cutaneous lymphomas (CLs) originate in the skin and should be differentiated from secondary skin infiltrates, which are manifestations of lymphomas of nodal or extranodal origin. These rare diseases include various lymphoproliferative disorders: cutaneous T-cell lymphomas, cutaneous B-cell lymphomas and some rare subtypes. As definitive cure is often not possible, it is important to con...

Introduction Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, highly aggressive hematopoietic malignancy. It manifests as cutaneous and bone marrow involvement and leukemic spread. It represents 0.7% of primary cutaneous lymphomas. Recently, it was established as a distinct entity. We present a rare case of BPDCN with good response to chemotherapy and review the clinicopathologic...

Mycosis fungoides (MF), also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma. Cutaneous lymphomas are an uncommon, heterogeneous group of non-Hodgkin lymphomas (NHLs) of T- and B-cell origin where the skin is the primary organ of involvement. This is a case of a 60-year-old Nigerian woman, who was diagnosed and managed as a case of ch...