PURPOSE To evaluate the long-term outcome of trabeculotomy-trabeculectomy as the primary surgical treatment for primary congenital glaucoma. METHODS Twenty-two eyes of 14 consecutive patients with primary congenital glaucoma who underwent combined trabeculotomy-trabeculectomy as the initial procedure between 1981 and 2005 were selected for review. Records of ocular family history, age at onse...

PURPOSE To assess the prognosis of different types of glaucoma in relation to unilateral and bilateral blindness at a University Hospital. METHODS Charts of glaucomatous patients which presented complete data of clinical history, visual acuity, visual field, fundus examination and diagnosis were retrospectively analyzed. The patients were classified as: not blind, legally blind (best correcte...

Glaucoma, the leading cause of irreversible blindness, appears in various forms. Mutations in CYP1B1 result in primary congenital glaucoma (PCG) by an autosomal recessive mode of inheritance while it acts as a modifier locus for primary open angle glaucoma (POAG). We investigated the molecular basis of the variable phenotypes resulting from the defects in CYP1B1 by using subclones of 23 CYP1B1 ...