Many neuronal cytosolic and nuclear proteins are post-translationally modified by the reversible addition of O-linked N-acetylglucosamine (O-GlcNAc) on serines and threonines. The cellular functions of O-GlcNAc modifications in neuronal development are not known. We report that O-GlcNAc-modified proteins are distributed nonuniformly throughout cultured primary chicken forebrain neurons, with in...

Dendrite arborization patterns are critical determinants of neuronal function. To explore the basis of transcriptional regulation in dendrite pattern formation, we used RNA interference (RNAi) to screen 730 transcriptional regulators and identified 78 genes involved in patterning the stereotyped dendritic arbors of class I da neurons in Drosophila. Most of these transcriptional regulators affec...

The maxn algorithm (Luckhardt and Irani, 1986) for playing multiplayer games is flexible, but there are only limited techniques for pruning maxn game trees. This paper presents other theoretical limitations of the maxn algorithm, namely that tie-breaking strategies are crucial to maxn, and that zerowindow search is not possible in maxn game trees. We also present quantitative results derived fr...

BACKGROUND Plants achieve remarkable plasticity in shoot system architecture by regulating the activity of secondary shoot meristems, laid down in the axil of each leaf. Axillary meristem activity, and hence shoot branching, is regulated by a network of interacting hormonal signals that move through the plant. Among these, auxin, moving down the plant in the main stem, indirectly inhibits axill...

We extend Sandholm’s bidtree-based IDA* algorithm for combinatorial auction winner determination to deal with negotiation over tasks with precedence constraints. We evaluate its performance, and show that the order of items in the bidtree has a major impact on performance. Specifically, performance is enhanced if the items with the largest numbers of bids are at the top of the bidtree. This is ...

In cities, trees are seen predominantly as entities that beautify streets, parks and gardens. Often they’re regarded obstacles to urban development, where their importance ecosystem health plays a secondary role economic growth. How can multispecies art offer new perspectives on crucial contributions life? Branching Songs is project with old in the Vancouver area, including ‘1308 Trees’, forest...