Summary Aziridines are useful synthetic building blocks, widely employed for the preparation of various nitrogen-containing derivatives. As current methods require use prefunctionalized amines, development a strategy toward aziridines that can establish union alkenes and amines would be great value. Herein, we report an electrochemical approach, which realizes this concept via oxidativ...

Methods for the assay of amino acids and peptides are most important in elucidating the structure of proteins and peptides. In many important areas of research such as in endocrinology, neurobiology, and genetics, methods are needed with sens itivity higher than is avai lable with the widely used colorimetric ninhydrin procedure. A short whi le ago, we noted that all primary amines react with n...

2-Aminoquinolin-4(1H)-one was reacted with various primary/secondary amines and paraformaldehyde under Mannich reaction conditions. In the case of secondary amines, the reaction in N,N-dimethylformamide yielded expected Mannich products accompanied with 3,3'-methylenebis(2-aminoquinolin-4(1H)-one). Except these main products, the pyrimido[4,5-b]quinolin-5-one derivative was also identified as c...

We demonstrate that the synthesis of new N-functionalized phosphinecarboxamides is possible by reaction of primary and secondary amines with PCO(-) in the presence of a proton source. These reactions proceed with varying degrees of success, and although primary amines generally afford the corresponding phosphinecarboxamides in good yields, secondary amines react more sluggishly and often give r...

In this review, we summarize recent progress from our group with regard to Pd-catalyzed oxidative amination of alkenes with amines. Intermolecular oxidative amination of alkenes with secondary anilines was induced using a palladium-complex catalyst combined with molybdovanadophosphate as a co-catalyst under dioxygen, leading to allylic amines and enamines in good yields with high selectivities....