This paper describes the design and development of an online immersive learning environment focused on supporting the general public in awareness of, and preparation for, crisis situations. The system developed uses the PANDORA + training environment, and integrates prior research work carried out on eLearning and Crisis Management. Specifically, it pulls together the outputs of three European ...

The current standard preparation for Class IV composite restorations is the placement of a bevel on all enamel margins. This study evaluated chamfered and beveled preparations for Class IV restorations of lesions with microfilled and macrofilled composite resin. Forty incisors were obtained and standardized lesions for Class IV restorations were formed. Twenty teeth had a 1.5-mm bevel placed an...

The goal of this article is to provide a largely self-contained introduction to the modelling of controlled quantum systems under continuous observation, and to the design of feedback controls that prepare particular quantum states. We describe a bottom-up approach, where a field-theoretic model is subjected to statistical inference and is ultimately controlled. As an example, the formalism is ...

We report a method for the preparation and selection of DNA-encoded dynamic libraries (DEDLs). The library is composed of two sets of DNA-linked small molecules that are under dynamic exchange through DNA hybridization. Addition of the protein target shifted the equilibrium, favouring the assembly of high affinity bivalent binders. Notably, we introduced a novel locking mechanism to stop the dy...

In comparative proteomic studies, it is important to know the variability associated with sample preparation. In this study, we report the strategy of using SILAC (stable isotope labeling by amino acids in cell culture) to evaluate the effect of the variation in sample preparation for quantitative proteomics. Variability can be measured when equal amounts of light and heavy SILAC samples underg...

Due to high aesthetic qualities, proven biocompatibility and prognosis for long term durability, porcelain veneers have become a routine restorative procedure for frontal teeth treatment. From a mechanical point of view, porcelain veneers are fragile and brittle before cementing. After fixation they gain the necessary pressure strength, and become more tensile and resistant to bending, which gu...

The activity of a ribozyme can be impaired by additional sequences at the 5' and 3' termini of the catalytic sequence. To approach this problem, a system was designed that minimizes sequences upstream and downstream from active regions of a hammerhead ribozyme and allows delivery of a large number of active molecules. A self-cleavable multimeric molecule was prepared by placing a ribozyme targe...

Effects of spinal cord injury induced changes in muscle activation on foot drag in a computational 1 rat ankle model 2 Brian K. Hillen 1,2 , Devin L. Jindrich 1,3 , James J. Abbas 1,2 , Gary T. Yamaguchi 4 , Ranu Jung 1,2,5 3 4 Contributions: 5 BKH was responsible for data collection, data analysis, experimental design, and the lead on manuscript 6 writing and figure design. 7 DLJ contributed t...

Abstract Bilevel optimization problems have received a growing attention in the recent past due to their relevance in practice. A number of studies on bilevel applications and solution methodologies are available for deterministic setup, but studies on uncertainties in bilevel optimization are rare. In this paper, we suggest methodologies for handling uncertainty in both lower and upper level d...