We have evaluated the perioperative effects of melatonin with those of midazolam in 75 women in a prospective, randomized, double-blind, placebo-controlled study. Patients were given sublingual midazolam 15 mg, melatonin 5 mg or placebo, approximately 100 min before a standard anaesthetic. Sedation, anxiety and orientation were quantified before, and 10, 30, 60 and 90 min after premedication, a...

BACKGROUND Glycopyrrolate given as reversing agents of muscle relaxants has been reported to be effective in reducing postoperative catheter-related bladder discomfort (CRBD). However, it remains unclear whether glycopyrrolate as premedication is also effective. This study aims to investigate the effectiveness of glycopyrrolate as premedication on preventing CRBD in the post-anesthesia care uni...

Introduction: Laryngoscopy and tracheal intubation are powerful noxious stimuli that should be attenuated. Effect more severe in hypertensive patients. The present study evaluated the safe and clinically effective dose of oral pregabalin as premedication for attenuation of pressor response of airway instrumentation in controlled hypertensive patients. Methods: After ethical committee clearance ...

midazolam (dormicum) is a benzodiazepine in general anesthesia. midazolam is very suitable for premedication, induction, and maintenance pronounced anxiolytic action, sedation and amnesia, rapid onset of the action, virtually no impairment of cardiovascular or respiratory parameters in therapeutic doses, short duration of action, and excellent local tolerance are among its most important effect...