نتایج جستجو برای: prejunctional

تعداد نتایج: 297  

Journal: :British journal of anaesthesia 1993
Y Saitoh H Toyooka K Amaha

We have studied the relationship between post-tetanic twitch (PTT) and single twitch response after administration of vecuronium 0.2 mg kg-1 in 100 patients during neuroleptanaesthesia (NLA) (droperidol and fentanyl) and during anaesthesia with halothane, isoflurane, enflurane or sevoflurane (1 MAC in nitrous oxide and oxygen). Intervals from PTT1 to single twitch, and post-tetanic-count (PTC) ...

Journal: :British journal of anaesthesia 1982
Y N Singh I G Marshall A L Harvey

The effects of seven antibiotics (streptomycin, amikacin, polymyxin B, lincomycin, clindamycin, tetracycline and oxytetracycline) were compared with those of magnesium, tubocurarine and lignocaine in the frog sciatic nerve--sartorius muscle preparation, using intracellular recording techniques. All compounds except tubocurarine decreased end-plate potential quantal content. The prejunctional ef...

Journal: :Neuron 2012
Daniela Hernandez Ciara A. Torres Wanda Setlik Carolina Cebrián Eugene V. Mosharov Guomei Tang Hsiao-Chun Cheng Nikolai Kholodilov Olga Yarygina Robert E. Burke Michael Gershon David Sulzer

mTOR is a regulator of cell growth and survival, protein synthesis-dependent synaptic plasticity, and autophagic degradation of cellular components. When triggered by mTOR inactivation, macroautophagy degrades long-lived proteins and organelles via sequestration into autophagic vacuoles. mTOR further regulates synaptic plasticity, and neurodegeneration occurs when macroautophagy is deficient. I...

Journal: :The Journal of pharmacology and experimental therapeutics 2010
T J Searl E M Silinsky

Ethanol has been shown to have both presynaptic and postsynaptic effects on synaptic transmission. However, the mechanisms by which ethanol affects evoked neurotransmitter release have not been studied at the mouse neuromuscular junction, a synapse at which binomial analysis of neurotransmitter release and measurements of prejunctional ionic currents can be made. Ethanol (400 mM) increased neur...

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