Ubiquitously eXpressed Transcript isoform 2 (UXTV2) is a prefoldin-like protein involved in NF-?B signaling, apoptosis, and the androgen estrogen response. UXT-V2 cofactor transcriptional enhanceosome, its knockdown inhibits TNF-? -induced activation. Fbxo7 an F-box that interacts with SKP1, Cullin1 RBX1 proteins to form SCF(Fbxo7) E3 ubiquitin ligase complex. negatively regulates signaling thr...

Abstract High-risk medulloblastoma is one of the most recalcitrant pediatric cancers, and children with MYC-amplified disease frequently succumb to relapsed disease. Extensive analyses coding genome in this have characterized additional somatic events some subsets patients, though tumors lack targetable mutations do not yield insights regarding their aggressive behavior. At same time, known exh...