Preeclampsia is a pregnancy-induced hypertensive disorder that causes substantial maternal and fetal morbidity and mortality. Despite being a leading cause of maternal death and a major contributor to maternal and perinatal morbidity, the mechanisms responsible for the pathogenesis of preeclampsia are poorly understood. Recent studies indicate that women with preeclampsia have autoantibodies th...

Preeclampsia is a devastating pregnancy-associated hypertensive syndrome. Although it is quite common, the pathophysiology of preeclampsia is not yet clear and remains “a disease of theory”. Angiogenic defect hypotheses have been intensively investigated, and some biomarkers have been independently analyzed as pathogenic clinical target molecules without direct proof of their roles in preeclamp...

Preeclampsia is a serious and phenotypically heterogeneous vascular pregnancy disorder. Heme oxygenase-1 (HO-1) is a stress response enzyme that may protect the maternal endothelium and facilitate adequate metabolic adaptation to pregnancy by its antioxidant and anti-inflammatory functions. HO-1 stress response is modulated by HO-1 gene (HMOX1) polymorphisms. Individuals with the long allele of...

OBJECTIVE To assess whether women with a history of preterm birth, independent on the presence of prelabour rupture of the membranes (PROM) and growth deviation of the newborn, are more likely to develop preeclampsia with preterm or preterm birth in a subsequent pregnancy. METHODS We conducted a population-based cohort study, based on Medical Birth Registry of Norway between 1967 and 2012, in...

BACKGROUND Available evidence concerning the association between air pollution and preeclampsia is limited, and specific associations with early- and late-onset preeclampsia have not been assessed. OBJECTIVES We investigated the association, if any, between preeclampsia (all, early-, and late-onset) and exposure to nitrogen dioxide, nitrogen oxides, particulate matter with aerodynamic diamete...

BACKGROUND Preeclampsia is defined as new onset of hypertension and proteinuria at gestational week 20 or after. However, use of these measures to predict preeclampsia before its clinical onset is unreliable, and evidence suggests that preeclampsia, eclampsia, or hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome may develop without hypertension or proteinuria being evide...

Background: Preeclampsia has high prevalence and important complication. The relationship between Glucose- 6-Phosphate Dehydrogenas (G6PD) and preeclampsia are expressed previously but their relationships are controversial yet. Some studies confirm this possibility and some others dismiss it. So we decided to examine the relationship between G6PD activity and preeclampsia although it is not den...

Not long ago, women who experienced preeclampsia were reassured that there were no long-term health risks associated with their condition—with the notable exception of an increased risk of recurrent preeclampsia in future pregnancies. Although proteinuria and hypertension would sometimes take weeks or even months to resolve, spontaneous remission after delivery was the rule. Although preexistin...

Bergman, L. 2017. Cerebral biomarkers in women with preeclampsia. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1364. 98 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0057-3. Preeclampsia and eclampsia are among the most common causes of maternal and fetal mortality and morbidity worldwide. There are no reliable means to predict eclampsia o...

OBJECTIVE The purpose of this study was to develop a model for preeclampsia based on maternal demographic characteristics and medical history. STUDY DESIGN This was a screening study of 120,492 singleton pregnancies at 11-13 weeks' gestation, including 2704 pregnancies (2.2%) that experienced preeclampsia. A survival-time model for the gestational age at delivery with preeclampsia was develop...