Pharmaceutical industries and effluents of sewage treatment plants are the main sources of residual pharmaceuticals in water resources. These emergent pollutants may adversely impact the biophysical environment. Pharmaceutical industries often generate wastewater that changes in characteristics and quantity depending on the used manufacturing processes. Carbamazepine (CBZ), {5Hdibenzo [b,f]azep...

The eff ect of pre-treatment on the permeation property of the Nafi on ionomer membrane has been evaluated. The membranes were subjected to diff erent pre-treatment procedures, viz treated with acid at room temperature, boiling with acid or boiling with water followed by cold acid. Diff erent characterization techniques were used to understand the changes. From UV-Visib...

Macroautophagy (generally referred to as autophagy) mediates the bulk degradation of cytoplasmic contents, including proteins and organelles, in lysosomes. Rapamycin, a lipophilic, macrolide antibiotic, induces autophagy by inactivating the protein mammalian target of rapamycin (mTOR). We previously showed that rapamycin protects against mutant huntingtin-induced neurodegeneration in cell, fly ...

The objective of our work is to evaluate the scientific and economic potential of US application as a pre-treatment step in combination with UV to optimise the disinfection process of wastewaters. Ultrasound application of 20 s at low density of 30 W/l changed the particle size distribution (PSD) of the samples, the mean particle diameter dropped from 70 to 11 microm. Generally it is assumed th...

Hypertensive disorders in pregnancy deserve special attention in the setting of global public health. Currently, they represent the third cause of maternal mortality in the world and first in Brazil. From a practical standpoint, pre-eclampsia remains a syndrome that leads to serious repercussions on maternal and fetal mortality and its etiology is not well known. Currently, the best treatment f...

  Introduction: Early differentiation of biliary atresia from neonatal hepatitis is of utmost importance, since on time surgery of biliary atresia significantly improves the outcome. Hepatobiliary scintigraphy is an integral part of diagnosis work-up of these patients; however its specificity for diagnosis of biliary atresia is suboptimal. In this study we evaluated t...

Recent observations in two patients, one with AGAT deficiency (AGAT-D) and one with GAMT deficiency (GAMT-D), both diagnosed already at birth, provide first evidence for important therapeutic effects of pre-symptomatic treatment with creatine (Cr) supplementation in AGAT-D and Cr supplementation plus guanidinoacetate lowering strategies in GAMT-D. Although long-term data are lacking, the result...

The pretibial myxedema is a manifestation of Graves' disease characterized by accumulation of glycosaminoglycans in the reticular dermis. The dermopathy is self-limiting but in some cases may cause cosmetic and functional damage. Conventional treatment is use of topical steroids under occlusive dressing, however the intralesional application has shown good results. We present a case of pretibia...

Ito M. Circadian variation of QT interval dispersion: correlation with heart rate variability. J Electrocardiol 1997; 30: 205–10. [9] Cinca J, Moya A, Figueras J, Roma F, Rius J. Circadian variations in the electrical properties of the human heart assessed by sequential bedside electrophysiologic testing. Am Heart J 1986; 112: 315–21. [10] Huikuri HV, Yli-Mayry S, Linnaluoto MK, Ikaheimo MJ. Di...

A new edition is most welcome. When the book appeared in 1937 it was well in advance of anything then in print. There is again a great deal of recent work assimilated into the body of the various chapters. Among the names of contributors are many new ones,some of which have been prominent in the journals during the last 8 years. We miss the name of Homans and his beautiful article on thrombosis...