Paraquat (PQ) is an herbicide used extensively in agriculture. This agent is also suspected to be a risk factor for Parkinson's disease (PD) by harming nigro-striatal dopamine neurons. There is likely, genetic-based, individual variability in susceptibility to PQ neurotoxicity related PD. In this study, we measured the delivery of PQ to the brain after three weekly injections of PQ at 5 mg kg(-...

Purpose: Compared to the well-documented cytotoxic quaternary ammonium Benzalkonium chloride (BAK), Polyquaternium-1 (PQ) is proposed to be safer for the ocular surface. Using an established acute rabbit toxicological model, we tested the toxicological profiles of three topical antiglaucoma treatments: two commercially available fixed combinations of latanoprost/timolol containing 0.020% BAK (l...

The previous mapping lecture demonstrated how, in the absence of errors, STS mapping could be solved efficiently via a reduction to a well-known abstract problem called the consecutive-ones problem. The solution made use of a data structure called a PQ-tree which eloquently represents all possible orderings of the STS sites that are consistent with the data. The flaw in this approach, however, ...

background: paraquat (pq) poisoning is highly fatal; and therefore, clinicians should be familiar with prompt approach to and poor prognostic features of this type of poisoning. hence, in this study, clinical profile, management and outcome of a series of patients with pq poisoning are presented. methods: a retrospective review of medical records of patients poisoned with pq who were treated at...

BACKGROUND Vivax malaria remains a major cause of morbidity in the subtropics. To undermine the stability of the disease, drugs are required that prevent relapse and provide reservoir reduction. A 14-day course of primaquine (PQ) is effective but cannot safely be used in routine practice because of its interaction with glucose-6-phosphate dehydrogenase (G6PD) deficiency for which testing is sel...

Glutathione (GSH) is one of the most important antioxidants that plays an essential role in detoxification of reactive oxygen species (ROS) which oxidizes to glutathione disulfide (GSSG). Paraquat (PQ), awidely used herbicide, causes pulmonary injury with the productionof ROS. Excessive ROS accumulation as a consequence of PQ exposure are frequently targeted by GSH thereby oxidative stress lead...

Exposure to paraquat leads to acute lung injury and oxidative stress is widely accepted as a contributor to paraquat-induced acute lung injury. Recent studies have reported that consumption of water with dissolved molecular hydrogen to a saturated level (hydrogen water) prevents oxidative stress-induced diseases. Here, we investigated whether consumption of saturated hydrogen saline protects ra...

Cisplatin treatment has an overall 19% response rate in animal models with malignant tumors. Increasing gap junction activity in tumor cells provides the targets to enhance antineoplastic therapies. Previously, a new class of substituted quinolines (PQs) acts as gap junction enhancer, ability to increase the gap junctional intercellular communication, in breast cancer cells. We examined the eff...