The importance of the nuclear receptor peroxisome proliferator–activated receptor-g (PPARg) in regulating insulin resistance and blood pressure has been demonstrated in families with loss of function mutations. Gain of function mutations has been associated with severe obesity. However, previous population studies of the common variant Pro12Ala have produced conflicting results. As it is likely...

The aim of this research was to investigate the changes in milk yield and its composition, fatty acid profile and peroxisome proliferator-activated receptors gamma (PPARG) gene expression in adipose tissue of Iranian Holstein cattle in response to feeding isonitrogenous and isocaloric diets but formulated based on different oilseeds (soybean or canola seeds). Twenty cows were tested ra...

Peroxisome proliferator-activated receptors-g (PPARg) are ligand-inducible transcription factors of the nuclear hormone receptor superfamily. We examined the ef

BACKGROUND We investigated the potential of telmisartan to improve microvascular dysfunction induced by myocardial ischemia/reperfusion (I/R) injury by activating the peroxisome proliferator-activated receptor gamma (PPARG) pathway. METHODS Forty-eight male rabbits were randomly allocated into sham-operated, I/R, GW9662, telmisartan, telmisartan-GW9662, or candesartan groups. Rabbits were ane...

Unsaturated fatty acids are ligands of PPAR-g , which up-regulates genes involved in fatty acid transport and TAG synthesis and the insulin-sensitising adipokine adiponectin, which activates fatty acid b-oxidation via PPAR-a action in liver. We investigated the effect of dietary fatty acid interaction with PPARG, PPARA and ADIPOQ gene variants on plasma lipid and adiponectin concentrations in t...

BACKGROUND A population-based case control study was performed to determine the associations of Pro12Ala polymorphism in peroxisome proliferator-activated receptor-γ (PPARG) and Gly308Ala polymorphism in tumor necrosis factor-α (TNFA) genes in obese subjects. PATIENTS AND METHODS Of 1,400 eligible subjects, ≧20 years, we recruited only 1,127. For extreme phenotype case-control design, we eval...

Glioblastomamultiforme (GBM) is one of the most lethal forms of cancer, with a survival rate of only 13% to 27%within 2 years of diagnosis despite optimal medical treatment. We hypothesize that the presence of a unique IL-13Ra2 decoy receptor prevents GBM apoptosis. This receptor has a high affinity for interleukin13 (IL-13), binds the cytokine, and competitively inhibits the intracellular sign...

BACKGROUND Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are the main products of microbial fermentation in the gut and might mediate some of the effects of gut microbiota and nutrition on development, metabolism, and pathogenesis of obesity and other diseases. OBJECTIVE The objective of this study was to determine the effects of SCFAs on adipocyte differentiat...

This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure obesity, as well its comorbid conditions, order construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.c...

Pioglitazone is the most widely used thiazolidinedione and acts as an insulin-sensitizer through activation of the Peroxisome Proliferator-Activated Receptor-γ (PPARγ). Pioglitazone is approved for use in the management of type 2 diabetes mellitus (T2DM), but its use in other therapeutic areas is increasing due to pleiotropic effects. In this hypothesis article, the current clinical evidence on...