Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. PPAR-gamma regulates gene expression by forming a heterodimer with the retinoid X receptor (RXR) before binding to sequence-specific PPAR response elements (PPREs) in the promoter region of target genes, thereby regulating several metabo...

OBJECTIVE To explore association of peroxisome proliferator-activated receptor gamma (PPAR-γ) and phosphatase and tensin homolog (PTEN) expressions with prognosis of renal cell carcinoma (RCC). METHODS Our study subjects included 87 RCC tissues, 28 paracarcinoma tissues and 21 normal renal tissues. PPAR-γ and PTEN detection was conducted using immunohistochemistry staining. The association of...

The availability of high-affinity agonists for peroxisome proliferator-activated receptor/ (PPAR / ) has led to significant advances in our understanding of the functional role of PPAR / . In this study, a new PPAR / antagonist, 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), was characterized using in vivo and in vitro models. Orally administered GSK3787 caused...

Background. Peroxisome proliferator-activated receptor (PPAR)-g may counteract tissue fibrosis via its anti-inflammatory actions, while hypoxia, a new pro-fibrotic factor, reportedly modifies PPAR-g expression. However, the effects of hypoxia on the expression and anti-inflammatory actions of PPAR-g have yet remained to be clarified in renal tubular cells. Methods. Confluent human proximal rena...

Sambandam, Nandakumar, Dominique Morabito, Cory Wagg, Brian N. Finck, Daniel P. Kelly, and Gary D. Lopaschuk. Chronic activation of PPAR is detrimental to cardiac recovery after ischemia. Am J Physiol Heart Circ Physiol 290: H87–H95, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00285.2005.— High fatty acid oxidation (FAO) rates contribute to ischemia-reperfusion injury of the m...

The nuclear receptor peroxisome proliferator-activated receptor (PPAR) is activated by a diverse group of acidic ligands, including many peroxisome proliferator chemicals present in the environment. Janus tyrosine kinase-signal transducer and activator of transcription (JAK-STAT) signaling is activated by multiple cytokines and hormones and leads to the translocation of dimerized STAT proteins ...

The biology of Peroxisome proliferator-activated receptor (PPAR) alpha (α) and gamma (γ) has been intensely scrutinized for the last 20 years and the clinical use of both PPAR-α (fibrates) and PPAR-γ (thiazolididiones) agonists has led to the understanding of their key role in the treatment of hypertriglyceridemia and type 2 diabetes mellitus [1, 2]. In contrast, the understanding of PPAR delta...

In recent years, the study of the peroxisome proliferators activated receptor gamma (PPAR-gamma) as a potential target for cancer prevention and therapy has gained a strong interest. However, the overall biological significance of PPAR-gamma in cancer development and progression is still controversial. While many reports documented antiproliferative effects in human cancer cell and animal model...

The thiazolidinedione (TZD) class of peroxisome proliferator-activated receptor (PPAR) ligands, known for their ability to induce adipocyte differentiation and increase insulin sensitivity, also exhibits anticancer properties. Currently, TZDs are being tested in clinical trials for treatment of human cancers expressing high levels of PPAR because it is assumed that activation of PPAR mediates t...

Fatty acid metabolism is transcriptionally regulated by two reciprocal systems: peroxisome proliferator-activated receptor (PPAR) controls fatty acid degradation, whereas sterol regulatory element-binding protein-1c activated by liver X receptor (LXR) regulates fatty acid synthesis. To explore potential interactions between LXR and PPAR, the effect of LXR activation on PPAR signaling was invest...