نتایج جستجو برای: poorly water
تعداد نتایج: 644812 فیلتر نتایج به سال:
Low solubility compounds show dissolution rate limited absorption and hence poor absorption, distribution and target organ delivery. Improvement of aqueous solubility in such a case is valuable goal to improve therapeutic efficacy. Complexation with CDs by different methods like physical mixing, melting, kneding, spray drying, freeze drying, co-evaporation has been reported to enhance the solub...
The Hydrocortisone acetate (Figure 1) is a white crystalline powder; it melts at about 220°C with decomposition and is practically insoluble in water 1mg/100mL [2]. One method to overcome the poorly water solubility of HA is the use of cyclodextrins (CDs), which have been extensively studied [3]. CDs have been extensively used as complexing agents to improve the solubility of a variety of poorl...
Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalli...
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