نتایج جستجو برای: poor water solubility

تعداد نتایج: 788110  

2012
VIPIN K AGRAWAL AMRESH GUPTA SHASHANK CHATURVEDI

Over the past century, phytochemical and phyto pharmacological sciences established the compositions that are biological active and health promoting. Most of the biologically active constituents of plants are polar or water soluble molecules. However, water soluble phyto-constituents (like flavonoids, tannins, terpenoids, etc.) are poorly absorbed either due to their large molecular size which ...

1998
Craig R. MacKenzie J. Paul Fawcett David W. Boulton Ian G. Tucker

Propanidid is a short acting anaesthetic with poor solubility in water. It was formerly marketed for clinical use as an intravenous (i.v.) anaesthetic in Cremophor EL (Epontol, propanidid 50 mg ml) but this was withdrawn due to anaphylactoid reactions to the vehicle. This paper reports on an aqueous formulation using hydroxypropyl-b-cyclodextrin (HP-b-CD) as a solubiliser. Phase solubility anal...

2011
Singh Pooja

Loratadine, a Class II drug is a second generation antihistaminic agent, which is poorly water soluble with low bioavailability. Loratadine is practically insoluble in water and as such it exhibits poor variable oral bioavailability. Loratadine needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. In the present investigation, studies...

Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...

Pathak, Kamla, Sharma, Vijay,

It has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. In order to improve the bioavailability, the release behavior of such drugs should be improved. Although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced m...

Journal: :pharmaceutical and biomedical research 0
vijay sharma department of pharmaceutics, rajiv academy for pharmacy, n.h. #2, delhi – mathura road, p.o. chattikara, mathura, uttar pradesh – 281001, india kamla pathak department of pharmaceutics, pharmacy college saifai, uprims&r, saifai, etawah, uttar pradesh, india

it has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. in order to improve the bioavailability, the release behavior of such drugs should be improved. although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced m...

Bhanudas Shankar Kuchekar Minal Narkhede,

       Purpose of this study was to investigate the effect of the presence of the water soluble polymers viz HPMC, PVP and PEG 6000 on aqueous solubility and complexation abilities of felodipine with or without presence of β-cyclodextrin (βCD) and HPβCD by phase solubility studies. The data revealed the initial increase in drug solubility followed by plateau in t...

2016
Zih-Chan Lin Chiang-Wen Lee Ming-Horng Tsai Horng-Huey Ko Jia-You Fang Yao-Chang Chiang Chan-Jung Liang Lee-Fen Hsu Stephen Chu-Sung Hu Feng-Lin Yen

Exposure to particulate matter (PM), a major form of air pollution, can induce oxidative stress and inflammation and may lead to many diseases in various organ systems including the skin. Eupafolin, a flavonoid compound derived from Phyla nodiflora, has been previously shown to exhibit various pharmacological activities, including antioxidant and anti-inflammatory effects. Unfortunately, eupafo...

A Indurkhya R Kumar Maheshwari

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic and anti-inflammatory activities. It is practically insoluble in water. The effect of hydrotropes such as urea and sodium citrate and blends (urea + sodium citrate) on the solubility of aceclofenac was investigated. The enhancement in the solubility of aceclofenac was more than 5 and 25 folds in 3...

Journal: :مهندسی بیوسیستم ایران 0
حمیده سپردار دانش آموخته کارشناسی ارشد علوم و صنایع غذایی،گروه علوم و صنایع غذایی، دانشکده کشاورزی، دانشگاه آزاد اسلامی واحد شهرکرد ابراهیم رحیمی دانشیار، گروه علوم و صنایع غذایی، دانشکده کشاورزی، دانشگاه آزاداسلامی واحد شهرکرد ایمان شهابی قهفرخی استادیار گروه علوم و صنایع غذایی-دانشگاه زنجان

in the past decades, environmental pollution caused by plastic packing materials, restrictions of petroleum resources and their high price attracted many researchers to produce biodegradable packaging materials. poor mechanic properties and high water vapor permeability are two main defects of biodegradable polymers. nanotechnology is a modification method in this case. in the current study, th...

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