نتایج جستجو برای: polysialic acid

تعداد نتایج: 747457  

Journal: :Infection and immunity 2006
Subhashinie Kariyawasam Timothy J Johnson Lisa K Nolan

We have identified a 56-kb pathogenicity island (PAI) in avian pathogenic Escherichia coli strain O1:K1 (APEC-O1). This PAI, termed PAI I(APEC-O1), is integrated adjacent to the 3' end of the pheV tRNA gene. It carries putative virulence genes of APEC (pap operon), other E. coli genes (tia and ireA), and a 1.5-kb region unique to APEC-O1. The kps gene cluster required for the biosynthesis of po...

Journal: :Annals of the New York Academy of Sciences 2012
Ajit Varki Pascal Gagneux

Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of vertebrates and so-called "higher" invertebrates, and on certain bacteria that interact with vertebrates. This overview surveys examples of biological roles of sialic acids in immunity, with emphasis on an evolutionary perspective. Given the breadth of the subject, the treatment of individual topics is...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Abderrahman El Maarouf Yuri Kolesnikov Gavril Pasternak Urs Rutishauser

Under chronic conditions of neuropathic pain, nociceptive C terminals are lost from their target region in spinal lamina II, leading to reduced thermal hyperalgesia. This region of the spinal cord expresses high levels of polysialic acid (PSA), a cell surface carbohydrate known to weaken cell-cell interactions and promote plasticity. Experimental removal of PSA from the spinal cord exacerbates ...

Journal: :Vaccine 2006
Daniel M Stein John Robbins Mark A Miller Feng-Ying C Lin Rachel Schneerson

As polysialic acid (PSA), the capsule of Group B meningococcus (GBM) and Escherichia coli K1, is a component of mammalian glycopeptides, there is concern that vaccines against PSA could induce immunopathology. Purified PSA is not immunogenic; however, as a component of bacteria or bound to proteins, it induces protective antibodies. In this review, we did not unearth data indicating an associat...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Kyungtae Kang Sunghoon Joo Ji Yu Choi Sujeong Geum Seok-Pyo Hong Seung-Yeul Lee Yong Ho Kim Seong-Min Kim Myung-Han Yoon Yoonkey Nam Kyung-Bok Lee Hee-Yoon Lee Insung S Choi

The posttranslational modification of neural cell-adhesion molecule (NCAM) with polysialic acid (PSA) and the spatiotemporal distribution of PSA-NCAM play an important role in the neuronal development. In this work, we developed a tissue-based strategy for metabolically incorporating an unnatural monosaccharide, peracetylated N-azidoacetyl-D-mannosamine, in the sialic acid biochemical pathway t...

Journal: :Development (Cambridge, England). Supplement 1992
U Rutishauser

Many cell adhesion molecules have a distinct pattern of expression and well-defined role in cell-cell recognition. In contrast, NCAM is broadly expressed and perturbations of its function affect many diverse aspects of embryonic development. Evidence has been obtained suggesting that the molecule and its polysialic acid moiety serve not only to contribute to specific interactions, but also to r...

Journal: :Glycobiology 2000
N W Charter L K Mahal D E Koshland C R Bertozzi

In this study we demonstrate that polysialyltransferases are capable of accepting unnatural substrates in terminally differentiated human neurons. Polysialyltransferases catalyze the glycosylation of the neural cell adhesion molecule (NCAM) with polysialic acid (PSA). The unnatural sialic acid analog, N-levulinoyl sialic acid (SiaLev), was incorporated into cell surface glycoconjugates includin...

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