Multiple layer nanoparticles offers a likelihood of success in drug delivery, as it provides a solution for a more controllable drug release, as with such structures, control over the capsule wall thickness, permeability, stability, and degradation characteristics can be achieved (Kumar, 2008). Using PDMS microfluidic devices to synthesize polymeric multilayer microparticles has become popular ...

the present study involves preparation and evaluation of gastric-mucoadhesive microparticles with metformin hydrochloride as model drug for prolongation of gastric residence time. the microparticles were prepared by the emulsification solvent evaporation technique using polymers of carbomer 934p (c) and ethylcellulose (ec). the microparticles were prepared by emulsion solvent evaporation method...

In this research, the capabilities of Henna and Henna with chitosan microparticles adsorbents were studied in order to remove the ion Cd (II). Response Surface Method (RSM) and Central Composite Design (CCD) were used to minimize the number of experiments (21 runs) for Henna and (26 runs) for the Henna with chitosan microparticles. The parameters were pH (2-9), initial solution concentratio...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

during last two decades, polysaccharides such as alginate (alg) alone and in combination with other biopolymers are widely used in vaccine and drug delivery systems. the aim of the present work was to investigate the potential utility of microparticles made of alginate (alg) as new vehicles for improving nasal vaccine delivery. for this purpose, diphtheria toxoid (dt) was chosen as a model anti...

Incorporation of active substances in polymeric microparticles (microencapsulation) is an important technological strategy used the pharmaceutical industry to improve functionality, quality, safety and/or therapeutic efficiency preparations for different routes administration. The current focus research this field on encapsulation small molecules and macromolecules into based biocompatible synt...

  During last two decades, polysaccharides such as alginate (Alg) alone and in combination with other biopolymers are widely used in vaccine and drug delivery systems. The aim of the present work was to investigate the potential utility of microparticles made of alginate (Alg) as new vehicles for improving nasal vaccine delivery. For this purpose, diphtheria toxoid (DT) was chosen as a model an...

Host response to implanted biomaterials and medical devices poses tremendous challenges to their clinical applications. Today, the quest to mitigate this immunological attack for improved longevity of these devices remains daunting. This thesis aims to explore the use of anti-inflammatory drugs in minimizing the host response and improve the efficacy of implantable and transplantable therapeuti...