نتایج جستجو برای: polygenic dyslipidemia
تعداد نتایج: 16254 فیلتر نتایج به سال:
Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS) to investigate shared single nucleotide polymorphisms (SNPs) between blood lipids and immune-mediated diseases. We analyzed data from GWAS (n~200,000 individuals), applying new False Discover...
Available statistics and research reveal that most patients with diabetes die from cardiovascular diseases, mainly due to markedly advanced and untreated atherosclerosis. Although the risk of cardiovascular disease increases additively with the number of conventional risk factors, including diabetes, hypertension and dyslipidemia, these conventional risk factors cannot fully account for the ris...
PURPOSE Dyslipidemia, hypertension, and diabetes are well-established risk factors for cardiovascular disease (CVD). This study investigated the prevalence and management status of these factors for dyslipidemia among Korean adults aged 30 years old and older. MATERIALS AND METHODS The prevalence and management status of dyslipidemia, hypertension, and diabetes were analyzed among 12229 subje...
What is sex determination? Sex determination is the mechanism by which sexual organisms direct gonad development towards distinct but reproductively compatible outcomes. Molecular signaling cascades in the developing gonad provide instructions to the tissue to develop as male or female (or in some cases hermaphrodite), and these signals can be initiated in different ways. Sex can be determined ...
Context Severe obesity is one of the major features of Bardet-Biedl syndrome (BBS) and causes reduced life expectancy. Bariatric surgery is an effective treatment of morbid obesity. Data on the effect of bariatric surgery for monogenic obesity is essentially lacking. We present the clinical and metabolic 3-year follow-up of sleeve gastrectomy in a BBS patient. Case Description A 37-year-old o...
OBJECTIVE Experience of stressful life events is associated with risk of depression. Yet many exposed individuals do not become depressed. A controversial hypothesis is that genetic factors influence vulnerability to depression following stress. This hypothesis is often tested with a "diathesis-stress" model, in which genes confer excess vulnerability. The authors tested an alternative formulat...
Cite this article as: Sonya F. Foley, Katherine E. Tansey, Xavier Caseras, Thomas Lancaster, Tobias Bracht, Greg Parker, Jeremy Hall, Julie Williams and David Linden, Multimodal brain imaging reveals structural differences in Alzheimer’s disease polygenic risk carriers: A study in healthy young adultsImaging Alzheimer’s disease polygenic risk, Biological Psychiatry, http://dx.doi.org/10.1016/j....
The genetic variants identified by three large genome-wide association studies (GWAS) of educational attainment were used to test a polygenic selection model. Average frequencies of alleles with positive effect (polygenic scores or PS) were compared across populations (N=26) using data from 1000 Genomes. The PS of 161 GWAS significant SNPs in a recent meta-analysis was highly correlated to popu...
BACKGROUND AND AIMS A strong correlation exists between smoking and the use of alcohol and cannabis. This paper uses polygenic risk scores to explore the possibility of overlapping genetic factors. Those scores reflect a combined effect of selected risk alleles for smoking. METHODS Summary-level P-values were available for smoking initiation, age at onset of smoking, cigarettes per day and sm...
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