OBJECTIVE Idiopathic hirsutism (IH) or polycystic ovary syndrome (PCOS) are the most common causes of hirsutism which affects 5-10% of all women. The aim of this study was to evaluate the efficacy of flutamide plus diane 35 in the treatment of idiopathic hirsutism and polycystic ovary syndrome. MATERIALS AND METHODS 26 polycystic ovary syndrome and 24 idiopathic hirsutism patients were evalua...

OBJECTIVES We aimed to investigate whether glucocorticoid receptor gene polymorphisms are associated with clinical and metabolic profiles in patients with polycystic ovary syndrome. Polycystic ovary syndrome is a complex endocrine disease that affects 5-8% of women and may be associated with metabolic syndrome, which is a risk factor for cardiovascular disease. Cortisol action and dysregulation...

Information of 82 children in Finland, treated during the years 1974 to 1983 for polycystic kidney disease, was collected retrospectively. The occurrence was of the order of 1:8000 births. Fifty-one of the children had early lethal disease and 31 survived for over 28 days. These children came from 69 families. They were divided by family studies into three groups: autosomal dominant polycystic ...

Arrested follicular maturation is a characteristic feature of polycystic ovary syndrome (PCOS). Follicles mature in ovarian stroma composed of extracellular matrix (ECM). However, little is known of the expression of ECM genes in polycystic ovaries. The present study compares the expression levels of genes coding for collagens, matrix metalloproteinases (MMP), their inhibitors (TIMP) and cathep...

background: the purpose of the study was to examine whether patients with subclinical hypothyroidism (sch) should be excluded before making a diagnosis of polycystic ovary syndrome (pcos). methods: seven hundred sixteen patients, 462 with true pcos, 31 with pcos-sch, and 223 normal cycling women were enrolled. clinical, metabolic, and hormonal parameters among the groups were investigated. cont...

PURPOSE Chronic pain is a prominent feature of autosomal dominant polycystic kidney disease that is difficult to treat and manage, often resulting in a decrease in quality of life. Understanding the underlying anatomy of renal innervation and the various etiologies of pain that occur in autosomal dominant polycystic kidney disease can help guide proper treatments to manage pain. Reviewing previ...

A 32-year-old man was examined for primary infertility. Ultrasound and computed tomography (CT) abdomen scans showed the presence of polycystic horse shoe kidney (Figure 1). CT abdomen revealed cysts in liver and seminal vesicles (Figure 2). There were bilateral ureteric calculi. There were no cysts in the pancreas or spleen. His serum creatinine level was 0.9 mg/dL (79.6 mmol/L). The patient h...

Polycystic liver is the most common extra-renal manifestation associated with autosomal dominant polycystic kidney disease (ADPKD), comprising up to 80% of all features. Patients with polycystic liver often suffer from abdominal discomfort, dyspepsia, or dyspnea; however, there have been few ways to relieve their symptoms effectively and safely. Therefore, we tried transcatheter arterial emboli...

Biliary cysts in adult patients affected by polycystic liver disease are lined by cholangiocytes that proliferate, suggesting that initiation of cyst formation depends on proliferation. Here, we challenge this view by analyzing cyst-lining cell proliferation and differentiation in Cpk mouse embryos and in livers from human fetuses affected by Autosomal Recessive Polycystic Kidney Disease (ARPKD...