A review is given of the development of the concept of an artificial tympanic membrane. Starting with homologous tympanic membranes we compared biodegradable collagen materials (homologous and heterologous) and biodegradable synthetic materials, poly-glycolic acid, poly-lactic acid and poly-alpha-amino acids. As a non-degradable material microporous PTFE and bisphenol-A poly (carbonate) were in...

3D printing is a popular fabrication technique because of its ability to produce complex architectures. Melt-based widely used for thermoplastic polymers like poly(caprolactone) (PCL), poly(lactic acid) (PLA), and poly(lactic-co-glycolic (PLGA) their low processing temperatures. However, traditional melt-based techniques require temperatures pressures high enough achieve continuous flow, limiti...

Abstract Electrospun fibrous scaffolds capable of providing dual growth factor delivery in a controlled manner have distinctive advantages for tissue engineering. In this study, we investigated the formation, structure, and characteristics/properties bicomponent glial cell line-derived neurotrophic (GDNF) nerve (NGF) peripheral regeneration. GDNF NGF were incorporated into core-shell structured...

Abstract This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously into poly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunc...

Poly(lactic-co-glycolic) acid (PLGA) has attracted a considerable amount of interest for biomedical application due to its biocompatibility, tailored biodegradation rate (depending on the molecular weight and copolymer ratio), approval for clinical use in humans by the U.S. Food and Drug Administration (FDA), the potential to change surface properties to create better interaction with biologica...

The mechanical properties of a tissue engineering scaffold are particularly important when engineering soft tissues as it has been shown that mechanical stimulation during in vitro tissue development can modulate cell differentiation, increase extracellular matrix synthesis, and enhance the mechanical properties of cartilaginous, ligamentous, and smooth muscle containing tissues [1-5]. Unfortun...