Novel poly(N-isopropylacrylamide-co-N-tert-butylacrylamide)-grafted hyaluronan [P(NIPAAm-co-NtBAAm)g-HA] has been developed as a modified derivative to improve phase-transition characteristics of PNIPAAmg-HA, which has a lower critical solution temperature (LCST) of approximately 32 ̊C. This promising selfassembling biomaterial has potential as an injectable scaffold for in situ cartilage tissue...

Polymers that respond to small changes in environmental stimuli with large, sometimes discontinuous changes in their physical state or properties, are often called "smart" polymers. Poly(N-isopropylacrylamide), PNIPAAm, is one of the most representative smart polymer that exhibits a thermally reversible soluble-insoluble change in the vicinity of its lower critical solution temperature (LCST) a...

Thermo-sensitive hydrogels were prepared by graft copolymerization of Polyvenylalcohol and chitosan with N-Isopropylacrylamide via gamma radiation. Characterization of hydrogels such as DSC analysis and swelling and solubility tests in different ratios were investigated. DSC and solubility analysis showed chitosan and PVA and NIPAAm monomer were grafted via gamma radiation successfully. Results...

Living systems are composed of complex multicellular organizations containing various cell types spatially distributed in defined microenvironments. The intricate cell-cell and cell-matrix interactions in these microenvironments regulate the cell fate, differentiation of the cells, and functions of the associated tissues. Recreating these complex associations in vitro can be highly useful for f...

Hydrophobicity and oleophobicity are highly desirable properties for materials that are used in a wide range of applications. In this context, poly(tetrafluoroethylene) (teflon) is considered to be the “benchmark” low-surfacefree-energy material as it combines water repellence with other desirable properties. Unfortunately, the use of teflon comes with certain disadvantages, such as those resul...

Age-related macular degeneration (AMD) is a potentially blinding posterior segment disease; inflammatory responses and subretinal drusen formation lead to leaky blood vessels. The current treatment method involves intravitreal injections of anti-VEGF agents, which highly invasive requires frequent administered by trained personnel. Periocular such as trans-/intra-scleral would provide minimally...

We report on a capillary-based microfluidic platform for the fabrication of non-spherical sodium alginate microgels. The sodium alginate droplets were crosslinked off-chip in a mixture of barium acetate and glycerol solution. Novel morphologies such as tear drop, lamp-like, mushroom-like, double-dimpled and bowl-like microgels were fabricated by controlling the size, impact velocity (at the cro...

Submit Manuscript | http://medcraveonline.com Abbreviations: HPMC: Hydroxypropyl Methylcellulose; MC: Methylcellulose; PLGA: Poly (Lactide-co-Glycolide); CAP: Cellulose Acetate Phthalate; LCST: Low Critical Solution Temperature; UCST: Upper Critical Solution Temperature; PPO: Polypropylene Oxide; PEO: Polyethylene Oxide; MTA: Methozolamide; PNIPAAm: Poly (N-Isopropylacrylamide); GC: Guluronic A...