PositiveMathematical Programming (PMP) is one of themost commonly usedmethods for calibrating activity programming models. In this article we consider PMP as a calibration method for risk programming models with a mean-variance (E-V) specification. We argue that the restrictive theoretical assumptions employed by typical linear E-V models limit their applicability in analyzing the effects of de...

Peroxisomal proteins are synthesized on free polysomes and then transported from the cytoplasm to peroxisomes. This process is mediated by two short well-defined targeting signals in peroxisomal matrix proteins, but a well-defined targeting signal has not yet been described for peroxisomal membrane proteins (PMPs). One assumption in virtually all prior studies of PMP targeting is that a given p...

Introduction Washington State experienced a five-fold increase in deaths from unintentional drug overdoses between 1998 and 2014. The PMP collects data on controlled substances prescribed to patients and makes the data available to healthcare providers, giving providers another tool for patient care and safety. Optimal impact for the program depends on providers regularly accessing the informat...

Within the mated reproductive tracts of females of many taxa, seminal fluid proteins (SFPs) coagulate into a structure known as the mating plug (MP). MPs have diverse roles, including preventing female remating, altering female receptivity postmating, and being necessary for mated females to successfully store sperm. The Drosophila melanogaster MP, which is maintained in the mated female for se...

INTRODUCTION This chapter describes the characteristics of adult patients starting renal replacement therapy (RRT) in the UK in 2007 and the acceptance rate for RRT in Primary Care Trusts (PCT) or equivalent Health Authority (HA) areas in the UK. METHODS The basic demographics are reported for all UK centres and clinical characteristics of patients starting RRT from all except 1 centre in the...

OBJECTIVES To use the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database to develop an accurate and clinically meaningful preoperative mortality predictor (PMP) for general surgery on the basis of objective information easily obtainable at the patient's bedside and to compare it with the preexisting NSQIP mortality predictor (NMP). METHODS Data w...

Executive summary Backhaul is a crucial enabler for mobile operators deploying new high-capacity technologies like Long Term Evolution (LTE), as they look for a solution that meets their performance requirements and minimizes costs – in particular opex, the largest contributor to backhaul costs. Backhaul prominence will rise further with the deployment of small cells, and with the associated in...

OBJECTIVE Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). We investigated EMP and PMP numbers across a spectrum of autoimmune rheumatic diseases (AIRDs) with the aim of comparing the levels of, and relationship between, EMPs and PMPs. METHODS Patients with Systemic Lupus Erythematosus (SLE) (...

the two main approaches for estimating pmp are the synoptic and statistical techniques that their results are often different and selection of the appropriate option is difficult. in the most previous researches the frequency factor in the statistical method has been considered equal to 15 which this is the ultimate limit of frequency factor and the corresponding pmp is became too large. in the...

Human hepatic peroxisomal AGT (alanine:glyoxylate aminotransferase) is a PLP (pyridoxal 5'-phosphate)-dependent enzyme whose deficiency causes primary hyperoxaluria Type I, a rare autosomal recessive disorder. To acquire experimental evidence for the physiological function of AGT, the K(eq),(overall) of the reaction, the steady-state kinetic parameters of the forward and reverse reactions, and ...