We have calculated the dose enhancements close to metal implants in Gamma Knife radiosurgery using different beam sizes, i.e., 4, 8 and 18 mm collimator helmets sin addition to the previous calculations using the 14 mm collimator helmetd. For the 8 and 18 mm helmets, the obtained results were similar to those obtained using the 14 mm helmet, which can be explained by the similar beam profiles w...

A series of new ethylenediamine (en) platinum(IV) complexes of the type Pt((IV))enX(2)A(2), with X(2) = cyclobutane-1,1-dicarboxylato (CBDCA), dichloro or bis(decanoato) and A = acetato, dodecanoato, tetradecanoato, hexadecanoato, octadecanoato, adamantanecarboxylato (Ad) or 3alpha, 12alpha-diformoxy-5beta-cholato (DFCA) were synthesized and characterized by elemental analysis, infrared and NMR...

Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor growth. These efforts continue today with increased realization that new strategies are needed t...

Responses to Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin In this issue of Acta Cryst. D, Shabalin et al. (2015) critique and re-evaluate dozens of crystal structures in the PDB in which proteins are bound to the platinum compounds cisplatin or carboplatin. Investigators whose structures were critiqued were contac...

The synthesis of metal frameworks perforated with nanotunnels is a challenge because metals have high surface energies that favor low surface area structures; traditional liquid-crystal templating techniques cannot achieve the synthetic control required. We report a synthetic strategy to fabricate metal nanomaterials with highly ordered, tunable mesostructures in confined systems based on a new...

In this study, high current densities si.e., 0.9 A/cm2d have been obtained in a hydrogen/air polymer electrolyte fuel cell using nanoscale tungsten carbide as the anode catalyst and carbon supported platinum as the cathode catalyst under normal operating conditions of 80 °C and 3 atm. These results show a possibility of replacing precious metal anode catalysts with transition metal compounds fo...

the development of metal-based therapeutics. Cisplatin is one platinum complex and is widely used in treatments for cancer. Shimizu and Tsuji established a method of preparing colloidal platinum particles, whose average size is 2 nm, by ethanol reduction of H2PtCl6 in the absence of protective agents such as hydrophilic polymers. They used only the chemicals permitted to food additives such as ...

Catalysing the reduction of oxygen in acidic media is a standing challenge. Although activity of platinum, the most active metal, can be substantially improved by alloying, alloy stability remains a concern. Here we report that platinum nanoparticles supported on graphite-rich boron carbide show a 50-100% increase in activity in acidic media and improved cycle stability compared to commercial c...

successful complete regression of these large tumors in 63 to 100% of the animals. c1L@@@†• Chart 1. Structural diagrams of the 2 platinum compounds found to be active against Sarcoma 180 and Leukemia L1210 in mice: the octahedral complex, cis-Pt(I\')(NH3)@CL@and the square planar com plex, cis-Pt(II)(NH3)2Cl2. MATERIALS AND METHODS Random-bred Swiss white mice, obtained from Spartan Research...