background : the aim of this study was to evaluate the antimalarial effects of iranian flora artemisia khorassanica against plasmodium berghei in vivo and pharmacochemistry of its natural components. methods : the aerial parts of iranian flora a. khorasanica were collected at flowering stage from khorassan province, northeastern iran in 2008. they were air-dried at room temperature; powder was ...

background: the worldwide distribution of p. vivax has expanded significantly and the number of reported cases has been on the rise. approximately 88% of malaria cases in iran are caused by plasmodium vivax , and in order to management of the disease, understanding the population genetic structure of the parasite is necessary for designing and applying drugs and vaccines. among many potential c...

background: there were about of 124 to 283 million cases of malaria with 367,000 to 755,000 deaths annually. this study aimed to assess the prevalence of malaria cases and associated risk factors among attendants at chichu and wonago health centers, south ethiopia. methods: in this health institution based cross sectional study, 324 subjects, attendants from outpatient department who came for a...

Plasmodium spp. are pathogenic to their vertebrate hosts and also apparently, impose a fitness cost on their insect vectors. We show here, however, that Plasmodium-infected mosquitoes survive starvation significantly better than uninfected mosquitoes. This survival advantage during starvation is associated with higher energy resource storage that infected mosquitoes accumulate during period of ...

Plasmodium cysteine proteases are essential for host-cell invasion and egress, hemoglobin degradation, and intracellular development of the parasite. The temporal, site-specific regulation of cysteine-protease activity is a prerequisite for survival and propagation of Plasmodium. Recently, a new family of inhibitors of cysteine proteases (ICPs) with homologs in at least eight Plasmodium species...

Plasmodium vivax is the most prevalent human malaria parasite outside of Africa. Yet, studies aimed to identify genes with signatures consistent with natural selection are rare. Here, we present a comparative analysis of the pattern of genetic variation of five sequenced isolates of P. vivax and its divergence with two closely related species, Plasmodium cynomolgi and Plasmodium knowlesi, using...

Plasmodium infection (mainly p. falciparum) is usually complicated by cerebral malaria, haemolysis, acute kidney injury and respiratory distress. Myocardial involvement is a rare complication of plasmodium infection. We have reported a case of plasmodium infection (p. vivax) complicated by myocarditis.

Examination of blood smears obtained from raptors trapped while on migration at Eilat, Israel, demonstrated Plasmodium infection in Accipiter brevipes and Buteo buteo. The following species are described, from A. brevipes: Plasmodium alloelongatum n. sp., P. accipiteris n. sp. and from B. buteo: P. buteonis n. sp. and Plasmodium sp. for which we lack sufficient data for adequate species descrip...

Malaria is a vector-transmitted disease with high number of cases. Plasmodium parasites are transmitted from the body Anopheles mosquito to host through several organs, including salivary glands and midgut. The midgut, apart being breeding ground for parasites, known studies that various types microbiota inhabit these two organs. group bacteria most widely be associated mosquitoes. found were d...

Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay an...