The objectives were to examine changes in the insulin response during pregnancy, lactation, and postweaning in an experiment involving 10 primiparous Landrace x Large White gilts. Gilts were catheterized at 50 d of pregnancy, and tests were conducted at approximately 59 d of pregnancy (midpregnancy; MP), 106 d of pregnancy (end of pregnancy; EP), 17 d of lactation (L), and 9 d after weaning (PW...

Insulin resistance is common among children with overweight and obesity. However, knowledge about glucose fluctuations in these children is scarce. This study aims to evaluate glycaemic profiles in children with overweight and obesity in free-living conditions, and to examine the association between glycaemic profiles with insulin resistance and cardiovascular risk parameters. One hundred eleve...

Abstract We evaluated how metabolizable energy (ME) intake influences antepartum insulin sensitivity in beef cattle. Angus-Simmental cattle (primiparous: n = 17; multiparous: 21) were randomly assigned to treatments supplying 80 (LowME, 19) or 120% (HighME, of predicted ME requirements for 53 d prepartum. At 7 antepartum, intravenous glucose tolerance tests (IVGTT) imposed by infusing 1.36 g gl...

Background: S-methyl cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in garlic and onion. The purpose of the present study was to investigate the protective effect of SMC on oxidative stress, inflammation and insulin resistance in an experiment of metabolic syndrome.Methods: Male Wistar rats were divided into five groups (6 rats in each group), namely; control, cont...

Dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. The aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). In this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

BACKGROUND Thyroid hormones (TH) may influence glucose metabolism. Hyperthyroid subjects have higher insulin secretion rates when compared with euthyroid individuals. OBJECTIVE To evaluate the association between TH concentrations and insulin secretion in euthyroid, healthy Pima Indian adults (n=55, 29+/-7 years, females/males 36/19) with normal glucose tolerance (NGT) admitted to a Clinical ...

The objective of the study was to examine the evolution of insulin sensitivity in a group of patients with stable coronary artery disease receiving one of four different pharmacological therapies. Insulin sensitivity was evaluated using an insulin suppression test in 40 newly diagnosed patients with coronary artery disease and no previous history of metabolic disorders, who were not taking any ...

We examined the cross-sectional association between plasma 25-hydroxyvitamin D [25(OH)D] and markers of the insulin resistant phenotype. Plasma 25(OH)D concentrations were measured in 808 nondiabetic participants of the Framingham Offspring Study. Outcome measures included fasting and 2-h post 75-g oral glucose tolerance test (OGTT) glucose and insulin; these were used to calculate the homeosta...

OBJECTIVE To study the influence of zygosity on the metabolic variables involved in the pathophysiology of type 2 diabetes. DESIGN Population based cross sectional study. SETTING Odense University Hospital, Denmark. PARTICIPANTS 125 monozygotic twin pairs and 178 dizygotic twin pairs of the same sex born between 1921 and 1940. MAIN OUTCOME MEASURES Clinical characteristics of monozygoti...