Arecoline Absorption after dermal application Hayes et al. (1989) developed a gas chromatography–mass spectrometry (GC–MS) technique for quantitative analysis of arecoline in blood plasma, in the concentration range 1–50 ng/mL, which was used on plasma samples from healthy volunteers [number not given] who had received transdermal doses at 3 mg/h. The time–concentration profile showed a maximum...