•The phase III IMpassion131 trial evaluated atezolizumab combined with paclitaxel as first-line therapy for aTNBC.•The primary endpoint was investigator-assessed PFS, tested hierarchically in the PD-L1+ and then ITT populations.•Neither PFS nor OS improved combination of plus either population.•These findings may result from imbalances prognostic features or chance a relatively small trial.•IMp...

Abstract Background Hereditary transthyretin-mediated (hATTR) amyloidosis, also known as ATTRv is a rapidly progressive, multisystem disease. Orthostatic hypotension, due to autonomic neuropathy, common yet hard-to-treat disease manifestation in patients with hATTR amyloidosis. Fatigue, muscle weakness, and deterioration cardiac function further exacerbate orthostatic symptoms. Efficacy of RNAi...

Objective: Long term use of opioids and benzodiazepines are associated with important untoward effects. The α2 adrenergic agonist clonidine has sedative effects. Our goal was to study clonidine addition to total doses of fentanyl and midazolam and duration of ventilation in pediatric ICU (PICU). Methods: This randomized, double-blind, placebo-controlled trial was conducted in PICU of Mofi...

Abstract Background Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Efficacy and safety tofacitinib were demonstrated in OCTAVE clinical programme.1,2 Here, we present analysis number causes UC-related hospitalisations during programme. Methods This descriptive comprised patients (pts) hospitalised UC who received placebo or 10 mg twic...

Abstract Background The clinical utility and long-term effects of endothelin receptor antagonists (ERAs) in Fontan-palliated patients remain unclear there are currently no approved therapies. A decline peak VO2 between consecutive cardiopulmonary exercise tests (CPETs) is highly prognostic for death or transplant adult Fontan patients, hence its use as a primary endpoint trials ERAs with circul...

Nigella sativa, Conyza bonariensis, and Alchemilla vulgaris are highly recommended in Greco-Arab traditional medicine as anti-hemorrhoid medicinal plants. The efficacy safety of a topical cream (HPC) consisting water–ethanol extracts these three plants were evaluated here vitro randomized, double-blind, placebo-controlled study (RDBPC). HPC showed no significant cytotoxic effects fibroblast cel...

Background: Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular disease. We investigated whether sleeping at altitude increases nocturnal heart rate (HR) and other markers of risk or arrhythmias in lowlanders COPD this can be prevented by oxygen therapy (NOT). Methods: Twenty-four patients, median age 66 years forced expiratory volume 1 s (FEV ) 55% predicted, living ...

Abstract Background The APP gene is located on chromosome 21 and thought to lead overproduction of beta‐amyloid (Aβ) in persons with trisomy (Down syndrome, DS). As a result, individuals DS are at high risk for developing Alzheimer’s disease (AD). ACI‐24 liposomal, T‐cell independent, anti‐Aβ vaccine which was assessed world’s first clinical phase 1b study adults DS. Method primary objectives t...

aim : we aimed to evaluate the efficacy of a synbiotic containing bacillus coagulans in treatment of ibs. background : some studies have shown the efficacy of probiotics in the treatment of irritable bowel syndrome (ibs). patients and methods : adult ibs patients (n=85) were randomized to receive a synbiotic containing bacillus coagulans or placebo for 12 weeks. frequency of ibs symptoms includ...