Near-infrared photoimmunotherapy (NIR-PIT), a promising cancer therapy utilizing an antibody-photoabsorber conjugate (APC) and NIR light, which induces rapid necrotic cell death only in APC-bound cells. Effective NIR-PIT in mouse models has been achieved using superficial light illumination (SLI) with light emitting diodes (LEDs) or lasers, but in the clinical setting, fiber optic diffusers hav...

A long held view about the occupation of southern proto-Jê pit house villages of the southern Brazilian highlands is that these sites represent cycles of long-term abandonment and reoccupation. However, this assumption is based on an insufficient number of radiocarbon dates for individual pit houses. To address this problem, we conducted a programme of comprehensive AMS radiocarbon dating and B...

The ecohydrological controls on soil erosion and landscape evolution are difficult to quantify and poorly understood. In many parts of the world, cyclone-induced tree throw is a major source of disturbance. Tree throw may increase sediment transport by exposing a mound of fresh soil as well as providing a pit which may act as a knickpoint triggering gully erosion. Alternatively, while tree thro...

One of the main concerns of the mining industry is to determine ultimate pit limits. Final pit is a collection of blocks, which can be removed with maximum profit while following restrictions on the slope of the mine’s walls. The size, location and final shape of an open-pit are very important in designing the location of waste dumps, stockpiles, processing plants, access roads and other surfac...

Pavlovian conditioned stimuli can influence instrumental responding, an effect called Pavlovian-instrumental transfer (PIT). During the last decade, PIT has been subdivided into two types: specific PIT and general PIT, each having its own neural substrates. Specific PIT happens when a conditioned stimulus (CS) associated with a reward enhances an instrumental response directed to the same rewar...

BACKGROUND AND OBJECTIVES Fluoride is being used for the prevention of dental caries since a long time. Incorporation of fluoride in pit and fissure sealants has been found to reduce initiation and progression of pit and fissure caries. Authors conducted this study to evaluate and compare the effect of fluoride releasing pit and fissure sealants on the inhibition of demineralization of adjacent...

P it vipers (e.g., rattlesnakes), boas, and pythons possess facial pit organs that are part of unique infrared imaging sensors not found in any other living species. Pit organs allow these snakes to detect thermal contrast in the environment and to form spatial images of their thermal environments within infrared regions of the electromagnetic spectrum (1) (Figure 1). The infrared imaging syste...

The Ecology contribution to address this question is to determine possible physicochemical impacts on 1) pond water quality and biological integrity, and 2) avulsed pit pond water quality and biological integrity in the historical pit location and receiving waters. These questions will be addressed by all study partners together in a more comprehensive fashion after the interim phase of reporting.

Sungun Copper Mine is located in an area with a high level of seismic hazard. Most recently, the Ahar-Varzeqan earthquake with a magnitude of 6.2 on Richter scale occurred on August 11, 2012; at a distance about 40 kilometers away from the mine. Nevertheless, the seismic stability of the final pit wall has not been comprehensively reviewed. In this research, the southwestern wall of the final p...

Six patients with open-angle glaucoma and acquired pit-like changes in the optic nerve head are presented. In 1 patient evolution of the pit-like defect is documented. In all 6 patients progression of associated visual field deficits is described. It is suggested that such pit-like changes in selected patients with glaucoma may not represent congenital lesions but rather local, progressive nerv...