INTRODUCTION The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. METHODS Solid dispersion formulations with different carriers including crospovidone, microcrystalline cellulose, Elaeagnus angustifolia fruit powder, with different drug to carrier ratios were prepared employing cogrinding method. Dissolution st...

OBJECTIVE To evaluate the anti-inflammatory effect of Silymarin in patients with knee osteoarthritis (OA) in comparison with piroxicam and meloxicam. METHODS A double-blind clinical trial was performed at the Department of Rheumatology, Baghdad Teaching Hospital, Baghdad, Iraq during the period from October 2004 to September 2005, in which 220 patients (79 males and 141 females) with painful ...

A novel series of potentially biologically active 1,2-benzothiazine 1,1-dioxides--analogs of piroxicam (a recognized non-steroidal anti-inflammatory drug) were synthesized from commercially available saccharin. All of the synthesized compounds were subjected to preliminary evaluation for their ability to interact with lipid bilayers. The influence of the new derivatives of piroxicam on liposome...

Successful management of endodontic pain represents a continuing challenge. The purpose of this randomized, double-blind, placebo-controlled, parallel-group trial was to compare the pain reducing effect of oral preparations of meloxicam, piroxicam, and placebo in endodontic emergency patients. A total of 51 patients who presented to the Tehran University endodontic clinic and one private dental...

A new 2:1 co-crystal of piroxicam and gentisic acid [systematic name: 4-hy-droxy-1,1-dioxo-N-(pyridin-2-yl)-2H-1λ6,2-benzo-thia-zine-3-carboxamide-2-(4-oxido-1,1-dioxo-2H-1λ6,2-benzo-thia-zine-3-amido)-pyridin-1-ium-2,5-di-hydroxy-benzoic acid, 2C15H13N3O4S·C7H6O4] has been synthesized using a microfluidic platform and initially identified using Raman spectroscopy. In the co-crystal, one piroxi...

Background: To investigate the effect of administering piroxicam on improving the success rate of IUI cycles in those suffering from unexplained infertility. Materials and Methods: This was a randomized clinical trial being performed at Ghadir Mother and Child Hospital and Motahari clinics of Shiraz University of Medical Sciences. We included 260 women with unexplained infertility selected for ...

Photosensitivity Ampiroxicam Piroxicam Photopatch test Minoru Chishiki, MD, Department of Dermatology, National Defense Medical College, Namiki 3-2, Tokorozawa City, Saitama 359 (Japan), Tel. +81 429 95 1665, Fax +81 429 96 5209 Piroxicam is known to induce photosensitivity. Ampiroxicam has been developed as an ethoxycarbonyl ether prodrug of piroxicam. We describe here a case with photosensiti...

Drug fraction transported from a topical formulation on skin to subcutaneous tissues or muscles is dependent on the physicochemical properties of the entrapped drug. Cutaneous disposition of model drugs, antipyrine (ANP), lidocaine (LC) and piroxicam (PXC) as well as flurbiprofen (FP) was thus evaluated in hairless rats in which an agar gel disc was subcutaneously inserted into the abdominal re...