Widely accessible food phytochemicals such as curcumin have been reported to anti-inflammatory and anticarcinogenic properties. However, has poor absorption in the gut, piperine of interest a dietary compound that can enhance bioavailability. The aim this study was develop optimize technique using reversed-phase chromatography with multi-wavelength detection for simultaneous measurement various...

BACKGROUND Exercise promotes energy metabolism (e.g., metabolism of glucose and lipids) in skeletal muscles; however, reactive oxygen species are also generated during exercise. Various spices have been reported to have beneficial effects in sports medicine. Here, we investigated the effects of piperine, an active compound in black pepper, to determine its effects on metabolism during acute end...

Several dietary and medicinal herbs have been shown to be effective in the treatment prevention of cancer. Although Piper nigrum has anti-cancer activities against various cancer cells, its anti-pancreatic properties not reported. In present study, P. extract (PNE) inhibited proliferation PANC-1 human pancreatic cells. Flow cytometry showed G0/G1 arrest caused by PNE addition, Western blot anal...

COVID-19 is now pandemic throughout the world, and scientists are searching for effective therapies to prevent or treat disease. The combination of curcumin piperine a potential option management based on several mechanisms including antiviral, anti-inflammatory, immunomodulatory, antifibrotic, antioxidant effects. Here, we describe probable mechanism curcumin-piperine against COVID-19. Adminis...

Mitochondrial dysfunction is the key pathogenic mechanism of cerebral injury induced by high-altitude hypoxia. Some Chinese herbal monomers may exert anti-hypoxic effects through enhancing the efficiency of oxidative phosphorylation. In this study, effects of 10 kinds of Chinese herbal monomers on mitochondrial respiration and membrane potential of cerebral mitochondria isolated from hypoxia-ex...

We searched in this study for novel agonists of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and transient receptor potential cation channel, subfamily A, member 1 (TRPA1) in pepper, focusing attention on 19 compounds contained in black pepper. Almost all the compounds in HEK cells heterogeneously expressed TRPV1 or TRPA1, increased the intracellular Ca(2+) concent...

Inhibitors of drug metabolism have important implications in pharmaco-toxicology and agriculture. We have reported earlier that piperine, a major alkaloid of black and long peppers inhibits both constitutive and inducible cytochrome P450 (CYP)-dependent drug metabolising enzymes. In the present study, an attempt has been made to prepare several novel synthetic analogues so as to relate various ...

AIM To study the effect of piperine on the epididymal antioxidant system of adult male rats. METHODS Adult male rats were orally administered piperine at doses of 1 mg/kg, 10 mg/kg and 100 mg/kg body weight each day for 30 consecutive days. Twenty-four hours after the last treatment, the rats were weighed and killed with ether and the epididymis was dissected from the bodies. Sperm collected ...

OBJECTIVES Bilateral destruction of the olfactory bulbs is known to cause behavioral changes analogous to symptoms of depression. Curcumin, a traditional Indian spice is currently being investigated in different psychiatric problems including depression. Dietary phytochemicals are currently used as an adjuvant therapy to accelerate their therapeutic efficacy. Therefore, the present study is an ...

Twelve methylenedioxy-containing compounds including piperine and 10 piperine-like synthetic compounds were assessed to determine their antifungal and antiaflatoxigenic activities against Aspergillus flavus ATCC 22546 in terms of their structure-activity relationships. Piperonal and 1,3-benzodioxole had inhibitory effects against A. flavus mycelial growth and aflatoxin B₁ production up to a con...