AIM To compare the risk of unplanned hospitalization in high-care nursing home residents taking Beers potentially inappropriate medications (PIM) against that of other elderly. METHODS Using an enhanced case-time-control design and conditional logistic regression applied to the pharmaceutical claims and other linked data of 245436 Western Australians aged ≥ 65 years (1993-2005), the study der...

BACKGROUND Ischemic preconditioning (IPC) and anesthetic-induced preconditioning against myocardial infarction are mediated via protein kinase B. Pim-1 kinase acts downstream of protein kinase B and was recently shown to regulate cardiomyocyte survival. The authors tested the hypothesis that IPC and anesthetic-induced preconditioning are mediated by Pim-1 kinase. METHODS Pentobarbital-anesthe...

In this study, we examined the expression of osteopontin (OPN), αvβ3 and Pim-1 in non-small cell lung cancer (NSCLC) and investigated the potential clinical implications of their expression patterns in NSCLC. Immunohistochemical assays were used to examine the protein expression of OPN, αvβ3 and Pim-1 in 208 NSCLC samples and their adjacent normal lung tissue specimens. Statistical analyses wer...

BACKGROUND Potentially inappropriate medication (PIM) use in the elderly is associated with increased risk of adverse drug reactions (ADRs), but there is limited information regarding PIM use in the intensive care unit (ICU) setting. OBJECTIVE The aim of the study is to describe the prevalence and factors associated with the use of PIM and the occurrence of PIM-related adverse reactions in th...

We previously demonstrated that the proto-oncogene Pim-3 with serine/threonine kinase activity was aberrantly expressed in cancer cells but not in the normal cells of the pancreas. In order to elucidate the molecular mechanism underlying aberrant Pim-3 expression in pancreatic cancer cells, we constructed luciferase expression vectors linked to 5'-flanking deletion mutants of the human Pim-3 ge...

BACKGROUND Drugs can be supplied either directly from the prescribing physician (physician dispensing [PD]) or via a pharmacy. It is unclear whether the dispensing channel is associated with quality problems. Potentially inappropriate medication (PIM) is associated with adverse outcomes in older persons and can be considered a marker for quality deficits in prescribing. We investigated whether ...

Intramuscular pressure (PIM) was measured simultaneously in zones of the medial head of the gastrocnemius-plantaris muscle group (zone I, popliteal origin; zone II, central; zone III, near calcaneus tendon) to determine regional muscle mechanics during isometric tetanic contractions. Peak PIM averages were 586, 1,676, and 993 mmHg deep in zones I, II, and III and 170, 371, and 351 mmHg superfic...

A Point Interpolation Method (PIM) is presented for stress analysis for two-dimensional solids. In the PIM, the problem domain is represented by properly scattered points. A technique is proposed to construct polynomial interpolants with delta function property based only on a group of arbitrarily distributed points. The PIM equations are then derived using variational principles. In the PIM, t...

Pim kinases are Ser/Thr kinases with multiple substrates that affect survival pathways. These proteins are overexpressed in acute myeloid leukemia (AML) blasts and we hypothesized that Pim kinase inhibition would affect AML cell survival. Imidazo[1,2-b]pyridazine compound, SGI1776 inhibits Pim-1, Pim-2 and Pim-3, and was evaluated in AML-cell line, -xenograft model, and -primary blasts. Treatme...

The serine/threonine kinase pim-1 mRNA contains a long and G/C rich 5'-untranslated region (5'-UTR). Previous work suggested that the pim-1 5'-UTR harbors an internal ribosomal entry site (IRES) allowing for internal initiation of translation. However, several previously reported eukaryotic IRES elements actually contain cryptic promoter activity. To test whether an IRES or a cryptic promoter i...