It has been suggested that single nucleotide polymorphisms (SNPs) in genes involved in Toll-like receptors (TLRs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. However, the extent to which these variations affect TLR signaling is not well understood. In this study, we adopted a bioinformatics approach to predict the consequences...

Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...

long-term potentiation (ltp) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. studies in recent years indicate the importance of molecular pathways in the development of memory and learning. tropomyosin receptor kinase b (trkb) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

background: the piwi-interacting rna (pirna) pathway has an essential role in transposon silencing, meiosis progression, spermatogenesis, and germline maintenance. hiwi genes are critical for pirna biogenesis and function. therefore, polymorphisms in hiwi genes contribute to spermatogenesis defects and can be considered as risk factors for male infertility. the aim of the present study was to i...

abstract background and objective: vascular abnormality and dysfunction plays an important role in the pathogenesis of vascular disease in diabetic state. in this study, we aimed to investigate whether an in vitro exposure of endothelium-intact aortic rings to melissa officinalis (lemon balm, mo) aqueous extract could have a beneficial effect in rats with subchronic diabetes. materials and meth...

sleep plays a vital role in regulating physiological mechanisms in the human body. nowadays, by the change of lifestyle and as a consequence of longer work hours and increased accessibility to media, sleep disturbance becomes a common problem in modern society. many studies demonstrated that sleep disturbance triggers a systemic low-grade inflammation by increasing the level of several cytokine...

av-node modification by catheter rf energy delivery is treatment of choice in the symptomatic patients with avnrt. this study included 30 patients with avnrt (19 women, 11 men). we did slow pathway ablation in 29 cases successfully. maximum effective energy delivery was 40 watts for 40 msec. 1:1 av conduction increased from 290±40 msec before ablation to 340±65 msec after ablation. also av-node...