BACKGROUND The regulation of adult stem cell migration through human hematopoietic tissue involves the chemokine CXCL12 (SDF-1) and its receptor CXCR4 (CD184). In addition, human leukocyte elastase (HLE) plays a key role. When HLE is located on the cell surface (HLE(CS)), it acts not as a proteinase, but as a receptor for α(1)proteinase inhibitor (α(1)PI, α(1)antitrypsin, SerpinA1). Binding of ...

Right ventricular outflow tract anomalies (RVOTAs), such as pulmonary stenosis (PS), atresia (PA), and insufficiency (PI), are typical cardiac in monochorionic twins, they complicated by twin-to-twin transfusion syndrome (TTTS). The aim of this study was to conduct a long-term postnatal cardiological evaluation prenatal RVOTAs diamniotic twin pregnancies TTTS treated with fetoscopic laser surge...

Eukaryotic phosphoinositide-specific phospholipases C (PI-PLC) specifically hydrolyze phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)], produce the Ca(2+)-mobilizing agent inositol 1,4,5-trisphosphate, and regulate signaling in multicellular organisms. Bacterial PtdIns-specific PLCs, also present in trypanosomes, hydrolyze PtdIns and glycosyl-PtdIns, and they are considered important vir...

New Zealand albino rabbits were inoculated in the right superior cervical ganglion with 25 microliter of herpes simplex virus type 1 (HSV-1) (McKrae strain; 10(3) or 10(5) PFU/ml). Positive tear film swabs were detected at least once in 28/32 (88%) of ipsilateral eyes and 6/32 (19%) of contralateral eyes beginning on postinoculation (PI) day 2-6. The average HSV-1 titer in the tear film was 4.0...

The influence of oxygen and temperature on the inactivation of pyruvate,Pi dikinase and NADP-malate dehydrogenase was studied in Zea mays. 02 was required for inactivation of both pyruvate,Pi dikinase and NADP-malate dehydrogenase in the dark in vivo. The rate of inactivation under 2% 02 was only slightly lower than that at 21% 02. The in vitro inactivation of pyruvate,Pi dikinase, while depend...

AIM To evaluate the long-term safety and effectiveness of lopinavir/ritonavir (LPV/r) in a population-based cohort of HIV-1-infected children. METHODS All children enrolled in the Swiss Mother and Child HIV Cohort Study, treated with LPV/r-based combination antiretroviral treatment (cART) between November 2000 and October 2008, were included. RESULTS 88 children (25 (28%) protease inhibitor...

Houmard, Joseph A., Christopher D. Shaw, Matthew S. Hickey, and Charles J. Tanner. Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E1055–E1060, 1999.—The purpose of this study was to determine if the improvement in insulin sensitivity with exercise training is associated with enhanced phosph...

The monocyte and granulocyte azurophilic granule proteinases elastase, proteinase 3, and cathepsin G are implicated in acute and chronic diseases thought to result from an imbalance between the secreted proteinase(s) and circulating serpins such as a1-proteinase inhibitor and a1-antichymotrypsin. We show here that the intracellular serpin, proteinase inhibitor 6 (PI-6), is present in monocytes,...