The synthesis, characterization and X-ray crystal structure of 2-(4-chloro-phenyl)-7-methylpyrrolo[1,2-b]pyridazine are reported. The compound crystallizes in the space group P2(1)/c (No.14) with a =3.8568(1), b = 11.0690(3), c = 26.4243(7) A, beta =92.777(1) degrees and Z = 4. Accurate molecular parameters for the novel heterocyclic system were obtained from intensity data collected at 113K. T...

Bronchoalveolar lavage (BAL) fluid was obtained from 24 sequentially studied patients with adult respiratory distress syndrome (ARDS) for assessment of potential activating and mediating factors. Proteolytic activity of the fluids was observed by measuring cleavage of radiolabeled proteins of the contact (Hageman factor) and complement systems. Proteolytic activity was observed in 17 of 24 (71%...

BACKGROUND Regulatory T cells (Treg cells), which are essential for regulation of immune response to respiratory syncytial virus (RSV) infection, are promoted by pharyngeal commensal pneumococcus. The effects of pharyngeal microflora disruption by antibiotics on airway responsiveness and relative immune responses after RSV infection have not been clarified. METHODS Female BALB/c mice (aged 3 ...

Molecules of the title compound [systematic name: 5-nitro-1H-isoindole-1,3(2H)-dione], C14H8N2O4, adopt a conformation in the solid state which renders them chiral, and they are linked by three distinct types of direction-specific intermolecular interaction. The molecules are linked by two C-H...O hydrogen bonds [H...O = 2.50 and 2.52 A, C...O = 3.118 (7) and 3.294 (7) A, and C-H...O = 123 and ...

7 Davis, J.A., Construction of relative difference sets in p-groups, Discrete Mathematics 103 (1992) 7-15. Jungnickel (1982) and Elliot and Butson (1966) have shown that (pi+ , p, pi+•, pi) relative difference sets exist in the elementary abelian p-group case (p an odd prime) and many 2-groups for the case p = 2. This paper provides two new constructions of relative difference sets with these p...

Perforin was purified to homogeneity from the murine cytotoxic T-lymphocyte cell line, CTLL-2 B 1 /6, by minor modifications of published methods [3]. In order to identify the maximum dose of perforin causing no lysis of KS62 cells (non-lethal dose), cells were incubated in Krebs-Hepes buffer with various doses o f perforin for 1 0 min at 37°C. Cell lysis was estimated by Trypan Blue uptake. Si...

In this paper some upper and lower bounds for the greatest eigenvalues of the PI and vertex PI matrices of a graph G are obtained. Those graphs for which these bounds are best possible are characterized.

The objective of this study was to evaluate relationships between rebreeding performance and growth performance (n = 3,777 gilts) and rebreeding performance and reproductive performance (n = 2,242 sows). Our data were from a selection experiment for shorter intervals from weaning to estrus after the first parity (IWE), involving Dutch Landrace pigs, in which a selection line and a control line ...

OBJECTIVE The redox pathophysiology of vascular repair is incompletely understood. We assessed the role of vascular superoxide dismutase (SOD) activity in oxidative/nitrative stress and caliber loss postinjury (PI). METHODS AND RESULTS Rabbits submitted to iliac artery balloon overdistension were followed for 14 days PI. Significant decrease in vascular SOD activity occurred at 7 and 14 days ...