نتایج جستجو برای: physiologic delivery
تعداد نتایج: 233784 فیلتر نتایج به سال:
Therapeutics based on RNA interference (RNAi) have emerged as a potential new class of drugs for treating human disease by silencing the target messenger RNA (mRNA), thereby reducing levels of the corresponding pathogenic protein. The major challenge for RNAi therapeutics is the development of safe delivery vehicles for small interfering RNAs (siRNAs). We previously showed that cholesterol-conj...
BACKGROUND AND PURPOSE Patients undergoing stent placement as treatment for severe stenosis of the internal carotid artery (ICA) were assessed with MR imaging in a combined MR-radiographic (XMR) angiography suite. MR imaging was performed before and immediately following conventional radiography-guided stent placement. Changes in MR imaging measurable properties, including flow and perfusion, r...
Dysregulated inflammation contributes to the pathogenesis of various diseases. Therapeutic efficacy of anti-inflammatory agents, however, falls short against resilient inflammatory responses, whereas long-term and high-dose systemic administration can cause adverse side effects. Site-directed drug delivery systems would thus render more effective and safer treatments by increasing local dosage ...
objective: several medications have been used for sedation in children in dentistry and intra-nasal route has been reported to be an efficient way regarding patient cooperation. the aim of the present study was to compare the changes in physiologic parameters following intra-nasal midazolam and ketamine administration. methods: in this randomized cross-over double-blind trial, 17 uncooperativ...
the aims of this study were to determine some major biochemical alterations observed in first calving cows with udder edema during the periparturient period and to detect some associations between dietary factors and the disease. for that, the concentrations of some electrolytes (na+, k+, cl, ca2+, p and mg2+), lipid (triglycerides and cholesterol) markers and lipoproteins (hdl, ldl and vldl) a...
Abstract The inspiring story of insulin pump development contains numerous hurdles overcome with leaps in technology. Miniaturisation and increased reliability have led to a discrete device that can deliver more physiologic profile than multiple daily injections. Accumulating evidence supports not only glycaemic benefits lower HbA 1c , reduced glucose variability hypoglycaemia rates but also im...
Purpose of review Automated insulin delivery using the subcutaneous site for both glucose sensing and insulin delivery, while not commercially available, is starting to be implemented in the research environment. Here, we review issues with glucose sensing and insulin delivery algorithms that need to be resolved in order to achieve a closed-loop system. Recent findings Glucose sensing technolog...
Several human and murine colon cancer cell lines have been established, physiologic integrity of colon tumors such as multiple cell layers, basal-apical polarity, ability to differentiate, and anoikis are not maintained in colon cancer derived cell lines. The present study demonstrates a method for culturing primary mouse colon tumor organoids adapted from Sato T et al. (1), which retains impor...
Both mineralo- and glucocorticoids stimulate renal Na-K-ATPase, but their relative role in the regulation of the enzyme remains controversial. In this study we measured Na-K-ATPase activity in the cortical collecting tubule (CCT) of adrenalectomized rats replaced with either the native mineralocorticoid (aldosterone) or glucocorticoid (corticosterone) in doses calculated to yield previously det...
in order to study planting date impacts and ending season drought stress on grain yield and gaining weight rate and wheat filling period characteristics in new advanced bread wheat genotypes ,this research is done by using plan statistical of spilt plot in form of complete random blocks basic plot with 3 replications in both common separated irrigation and ending season drought stress...
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