The neutral theory of molecular evolution predicts that variation within species is inversely related to the strength of purifying selection, but the strength of purifying selection itself must be related to physical constraints imposed by protein folding and function. In this paper, we analyzed five enzymes for which polymorphic sequence variation within Escherichia coli and/or Salmonella ente...

We have carried out molecular-dynamics simulations on fully flexible all-atom models of the protein lysozyme immersed in trehalose, an effective biopreservative, with the purpose of exploring the nature and extent of the dynamical coupling between them. Our study shows a strong coupling over a wide range of temperatures. We found that the onset of anharmonic behavior was dictated by changes in ...

Empirically derived models of amino acid replacement are employed to study the association between various physical features of proteins and evolution. The strengths of these associations are statistically evaluated by applying the models of protein evolution to 11 diverse sets of protein sequences. Parametric bootstrap tests indicate that the solvent accessibility status of a site has a partic...

Ionic liquids can be used as solvents for gas absorption operations in order to improve the process economy and general efficiency of gas separations. This work investigates solvent properties of ionic liquids and compares them to amine solutions used for absorption of carbon dioxide (CO2). The CO2 solubility into imidazolium-based Room Temperature Ionic Liquids (RTILs) was measured at temperat...

The interplay between ions and solvent molecules inside the nanoporous electrodes of a supercapacitor has not been well understood but could be a fertile ground for new insights into the device's performance. By tuning the dipole moment of the solvent in an organic electrolyte, we find, from classical density functional theory calculations, pronounced oscillation of capacitance with the pore si...

Submitted for the MAR13 Meeting of The American Physical Society In-situ Grazing-incidence Small-angle X-ray Scattering Study of Diblock Copolymer Thin Films during Solvent Annealing XIAODAN GU, University of Massachusetts Amherst, ILJA GUNKEL, ALEXENDER HEXEMER, Lawrence Berkeley National lab, THOMAS RUSSELL, University of Massachusetts Amherst, UNIVERSITY OFMASSACHUSETTS AMHERST COLLABORATION...

AIM The aim of the study was to examine possible neurotoxic effects on the central nervous system (CNS) in relation to a chronic solvent exposure at the workplace. METHOD The collective included 127 workers exposed to solvent mixtures, such as spray painters and printers. They were examined twice by means of a physical examination, neuropsychological testbattery, biological and air monitoring...

There are several reports about the optimization of protease production, but only few have optimized the production of organic solvent tolerant keratinolytic proteases that show remarkable exploitation in the development of the non-polluting processes in biotechnological industries. The present study was carried with aim to optimize the production of a thermostable organic solvent tolerant kera...

Present investigation describes preparation of microspheres by solvent evaporation followed by in vitro characterization of microspheres to evaluate the effect of method of preparation on physical properties and drug release profile of microspheres. The microspheres were found to be discrete, spherical with free flowing properties. The morphology (Scanning Electron Microscopy), particle size di...

Present investigation describes preparation of microspheres by solvent evaporation followed by in vitro characterization of microspheres to evaluate the effect of method of preparation on physical properties and drug release profile of microspheres. The microspheres were found to be discrete, spherical with free flowing properties. The morphology (Scanning Electron Microscopy), particle size di...