Photodynamic Therapies In article 2201613 by Chia-Hao Su, Chen-Sheng Yeh, and co-workers, the concept of self-supplying H2O2 O2 is presented an all-in-one nanoreactor to process generation, chemiluminescence resonance energy transfer (CRET) activated generated H2O2, energy-transfer excite photosensitizer resulting in singlet oxygen formation. This allows conduction external light-fee CRET-media...

The oxidative effects of photodynamic therapy with 5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (TMP) and Zn-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (ZnTMP) were evaluated in Wistar rats subcutaneously inoculated with Walker 256 carcinoma. The animals were irradiated with red light (λ = 685 nm; D = 50 J/cm2; 15 min) 3 h after intra-peritoneal administration of 10 mg/kg body weight of p...

Treatment of childhood rhabdomyosarcoma is limited by recurrent disease and the development of multidrug resistance. Therefore, novel treatment options are desirable. Photodynamic therapy (PDT) using the photodynamic agent hypericin is proposed as an alternative approach for intraoperative visualization and treatment of this disease. The aim of this study was to investigate in vitro effects of ...

Experiments were performed to determine whether the expression and/or repair of potentially lethal damage could be observed in mammalian cells exposed to hemataporphyrin derivative (HPD) photodynamic therapy (PDT). Photodynamic therapy was combined with posttreatment protocols known to inhibit the repair of potentially lethal damage in cells treated with X-rays, ultraviolet radiation, or alkyla...

Study is devoted to investigation of fluorescent and photodynamic properties of near-infrared photosensitizer bacteriochloriphyllide-serine. The peculiarities of its fluorescence excited by different lasers, dynamics and selectivity of accumulation were investigated. Photodynamic therapy of mice and investigation of tissue de-oxygenation during tumor irradiation were performed. It was shown tha...

An effective theranostic platform based on porous silica nanoparticles encapsulated with the complex of a photodynamic anticancer drug and graphene quantum dots (GQDs), with the bifunction of multicolor imaging and satisfactory photo-induced anticancer activity, was successfully designed and prepared for in vitro photodynamic therapy (PDT) of superficial cancer.

Introduction Studies in our laboratory focus on development of vascular targeted photodynamic therapy (VTP) based on bacteriochlorophyll derivatives as photosensitizer drugs, elucidation of its mechanism of action and development of new applications for photodynamic therapy (PDT) such as treatment of Extrauterine Pregnancy (EUP). These studies are in collaboration with Prof. Avigdor Scherz Dept...

Aflibercept (Eylea) injection (CPB 0701 Vascular Endothelial Growth Factor Inhibitors for Ocular Indications) Bevacizumab (Avastin) injection (CPB 0685 Bevacizumab (Avastin)) Pegaptanib sodium (Macugen) injection (CPB 0701 Vascular Endothelial Growth Factor Inhibitors for Ocular Indications) Photodynamic therapy (PDT) with light-activated verteporfin (CPB 0594 Visudyne (Verteporfin) Photodynami...

Objective(s)   Although photodynamic therapy is considered as a noninvasive method, most photosensitizers are susceptible to  ultrasound.  Therefore,  it  is  expected  that  the  combination of  two  activation  methods  might  have  a synergistic effect. This probable effect has been investigated in this study.   Materials and Methods   This  study  was  conducted  on  colon  carcinoma ...

Background & Aims: In this study with the aim of benefiting from non-laser sources in photodynamic therapy, photo and radio sensitivity of indocyanine green as a sensitizer in photodynamic and radiation therapies were investigated. Methods: Based on the broad absorption peak of indocyanine green and using non-coherent light, the experiments were performed on human cells derived from breast canc...