نتایج جستجو برای: phospholipase d pld

تعداد نتایج: 596477  

Journal: :The Biochemical journal 2000
M Liscovitch M Czarny G Fiucci X Tang

Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid. The activation of PLD is believed to play an important role in the regulation of cell function and cell fate. Multiple PLD activities were characterized in eukaryotic cells, and, more r...

Journal: :The Biochemical journal 1999
R R Bosch R L Smeets F Sleutels A M Patel S E Emst-de Vries J Joep H H de Pont P H Willems

Receptor-mediated activation of phosphatidylcholine phosphatidohydrolase or phospholipase D (PLD) was studied in Chinese hamster ovary (CHO) cells expressing the cholecystokinin-A (CCK-A) receptor. Cells were labelled with [3H]myristic acid for 24 h and PLD-catalysed [3H]phosphatidylethanol formation was measured in the presence of 1% (v/v) ethanol. Cholecystokinin-(26-33)-peptide amide (CCK8) ...

Journal: :Current Biology 1996
Michael A. Frohman Andrew J. Morris

Small GTP-binding proteins act as switches that control diverse cellular processes. Those in the ADP-ribosylation factor (ARF) class direct key steps in intracellular protein traffic, whereas those in the Rho family regulate gene transcription as well as changes in cell motility and morphology [1,2]. Several groups have now produced evidence that these regulatory activities of Rho and ARF prote...

Journal: :Plant physiology 2005
Xuemin Wang

Phospholipase D (PLD) hydrolyzes membrane lipids to generate phosphatidic acid (PA) and a free-head group (Fig. 1), and this activity is widespread in plants. Recent results indicate that PLD plays multiple regulatory roles in diverse plant processes, including abscisic acid (ABA) signaling, programmed cell death, root hair patterning, root growth, freezing tolerance, and other stress responses...

Journal: :Current Biology 2001
Alirio J. Melendez Margaret M. Harnett Janet M. Allen

Fc receptors play a pivotal role linking the cellular the mechanisms regulating receptor coupling to PLD in intact cells where the components are endogenously ex-and humoral arms of the immune system [1–3]. Our previous studies have shown that the human high-pressed and functional. First, the presence of specific PLD isozymes in the cell membrane fraction was exam-affinity immunoglobulin G rece...

2017
Keqian Hong Lubin Zhang Rulin Zhan Bingyu Huang Kanghua Song Zhiwei Jia

Phospholipase D (PLD) in plants plays vital roles in growth, development, and stress responses. However, the precise role of PLDs in pineapple remains poorly understood. In this study, 10 putative PLD genes, designated as AcPLD1-AcPLD10, were identified based on the pineapple genome database. The 10 AcPLDs could be clustered into five of the six known PLD families according to sequence characte...

Journal: :Endocrinology 2010
Haixia Qin Michael A Frohman Wendy B Bollag

In primary bovine adrenal glomerulosa cells, the signaling enzyme phospholipase D (PLD) is suggested to mediate priming, the enhancement of aldosterone secretion after pretreatment with and removal of angiotensin II (AngII), via the formation of persistently elevated diacylglycerol (DAG). To further explore PLD's role in priming, glomerulosa cells were pretreated with an exogenous bacterial PLD...

Journal: :Analytical biochemistry 2012
Le Duy Do René Buchet Slawomir Pikula Abdelkarim Abousalham Saida Mebarek

To determine phospholipase D (PLD) activity, an infrared spectroscopy assay was developed, based on the phosphate vibrational mode of phospholipids such as dimyristoylphophatidylcholine (DMPC), lysophosphatidylglycerol (lysoPG), dipalmitoylphosphatidylethanolamine (DPPE), and lysophosphatidylserine (lysoPS). The phosphate bands served to monitor the hydrolysis rates of phospholipids with PLD. T...

Journal: :Biochemical Society symposium 2007
Andrew J Morris

Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exocytosis and stimulation of cell growth and survival. PLD regulation and function are intimately linked with phosphoinositide metabolism. Phosphatidyl 4-phosp...

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