Abstract Individuals with migraine generally experience photophobia and/or phonophobia during and between attacks. Many different mechanisms have been postulated to explain these phenomena including abnormal patterns of connectivity across the cortex. The results, however, remain contradictory there is no clear consensus on nature cortical abnormalities in migraine. Here, we uncover alterations...

Introduction Migraine is a common and very disabling neurological disease. It typically causes severe throbbing pain or pulsing sensation, usually on one side of the head. It's often accompanied by nausea, vomiting, extreme sensitivity to light sound. According definition headache, should be located in head face above orbitomeatal line. Beyond this classical view, recent evidence has shown that...

A 17-year-old boy developed diffuse throbbing headache of 36 hours duration associated with photophobia and phonophobia. Twelve hours later, he developed dysarthria and rightsided weakness. He had a similar episode 5 months ago with resolution of symptoms in 24 hours, following which he was put on prophylactic sodium valproate 300 mg/day. His elder brother had suffered from intermittent diffuse...

A 45-year-old man with a history of hypertension and no tobacco exposure presented with a 13-year history of daily strictly right-sided continuous headache that began 2 months after concussion. His headache was associated with mild photophobia, phonophobia, nausea, and rare episodes of emesis as well as constant right-sided nasal stuffiness for “years.” Additionally, the patient would experienc...

Migraine is a brain disease whose principal symptom is episodic intense throbbing pain in the head which is often accompanied by photophobia, phonophobia, nausea and vomiting. Primary objectives of migraine treatment are to abort the acute attacks, treat associated symptoms and prevent future attacks. With a majority of migraine patients being young, they will need a treatment plan to suit thei...

Despite the huge progress in definition and classification of vestibular disorders within last decade, there are still patients whose recurrent symptoms cannot be attributed to any recognized episodic syndromes, such as Menière's disease (MD), migraine (VM), benign paroxysmal positional vertigo (BPPV), paroxysmia, orthostatic or transient ischemic attack (TIA). The aim present international, mu...

Introduction Migraine is a chronic disease and affects about 15% of the World population. It second most disabling among young adults. Pathophysiology has not yet been fully clarified, but there evidence for genetic alterations that cause state hyperexcitability metabolic make central nervous system more susceptible to external stimuli. Objective To present evolution diagnosis headache with aur...

Abstract Background Migraine is a chronic episodic neurological disorder characterized by myriad of symptoms including multi-phase attacks headache, photophobia, phonophobia, and dizziness. To the best our knowledge, there are no studies conducted about public perception attitudes towards migraine in Saudi Arabia. This study aims to determine Jeddah, cross-sectional was during period between Se...

Objective To determine the efficacy, tolerability, and safety of ascending doses of Adhesive Dermally-Applied Microarray (ADAM) zolmitriptan versus placebo for acute migraine treatment. Background ADAM is a novel patient-administered system for intracutaneous drug administration. In a phase 1 pharmacokinetic study, zolmitriptan administered using ADAM had much faster absorption than oral admini...

Case Presentation: A 20-year-old woman presented with 24 hours of severe left-sided headache associated with nausea, photophobia, and phonophobia. She was previously healthy and was taking only an oral contraceptive pill. On physical examination, she was tachycardic to 110 bpm, normotensive with a blood pressure of 108/64 mm Hg, and appeared uncomfortable. Neurological examination in the emerge...