Variations in the human karyotype have been found in association with a variety of congenital anomalies and also in the normal population (Miller and Mukherjee, 1962; Court Brown, 1967). Court Brown's population studies (1967) have revealed that between 2 and 3%o of the normal adult population has a karyotype with structural autosomal variations. Occasionally, homologous autosomes reveal differ...

Cigarette smoking appears to be on the increase in adolescents. The initiation of regular smoking nearly always begins before adulthood. It is therefore crucial to find ways of identifying those children most vulnerable to nicotine addiction and prioritizing them for preventive measures. We hypothesized that individuals who, in a simple taste test, perceive phenylthiocarbamide (PTC) as bitter m...

The cytotoxic activities of three new synthetic catechol analogues, beta-[(p-hydroxyphenyl)amino]alanine (Compound 1), N delta-(p-hydroxyphenyl)ornithine (Compound 2), and N delta-(m-hydroxyphenyl)ornithine (Compound 3), were determined against 10 human melanoma and 5 nonmelanoma cell lines. Activities of L-DOPA and 3,4-dihydroxybenzylamine were also measured. Dose-response curves were obtained...

This is a book, designed for popular consumption, that lists a number of normal characters held to be inherited in man. Many traits are scarcely "treasures," as might be inferred from the title. They pertain chiefly to physical characters, especially those of the face and other readily inspected areas. Much of the material would appear to have been obtained from students in the author's class o...

There have been few quantitative cross-cultural studies of taste and smell perception in humans, despite the obvious relevance of such research to scientific and commercial enterprises, and the fact that many cultures differ in their food preparation, dietary, and personal hygienic practices. The important role of the chemical senses to the species as a whole in such diverse matters as the dete...

Tyrosinase catalyzes the initial, rate-limiting step of melanin synthesis; oxidative conversion L-tyrosine to L-dopa followed by L-dopaquinone means oxygen molecule. possesses bicopper active center capable utilizing molecular oxygen. Metabolic rhododendrol (RD) tyrosinase causes leukoderma in a certain population consumers. Along with cytotoxic RD metabolites, reactive species (ROS) produced d...

Bitterness perception in mammals is mostly directed at natural toxins that induce innate avoidance behaviours. Bitter taste is mediated by the G protein-coupled receptor TAS2R, which is located in taste cell membranes. One of the best-studied bitter taste receptors is TAS2R38, which recognizes phenylthiocarbamide (PTC). Here we investigate the sensitivities of TAS2R38 receptors to PTC in four s...