A fast, accurate, precise and sensitive capillary electrophoresis method for the simultaneous determination of dextromethorphan hydrobromide, phenylephrine hydrochloride, paracetamol and chlorpheniramine maleate has been developed. Response surface methodology with a central composite design was used for optimization of the concentration of the buffer, pH of the buffer and applied voltage. Ther...

The Food and Drug Administration (FDA) is proposing new warning labeling for all over-the-counter (OTC) drug products containing phenylpropanolamine preparations (phenylpropanolamine bitartrate, phenylpropanolamine hydrochloride, and phenylpropanolamine maleate). Phenylpropanolamine is a sympathomimetic drug that is used in OTC weight control, cough-cold, nasal decongestant, and allergy drug pr...

Objective: Chemometric assisted spectrophotometry, and HPLC methods have been developed for the simultaneous determination of phenylephrine hydrochloride (PEPH), paracetamol (PCM), guaifenesin (GNF), chlorpheniramine maleate (CPM) and bromhexine hydrochloride (BRM). Methods: The chromatographic separation was carried out on a Phenomenex RPC18 column. An isocratic elution was carried out with th...

BackgroundImmunosuppression after surgery is associated with postoperative complications, mediated in part by catecholamines that exert anti-inflammatory effects via the β-adrenergic receptor. Phenylephrine, generally regarded as a selective α-adrenergic agonist, frequently used to treat perioperative hypotension. However, phenylephrine may impair host defence through affinity.MethodsHuman leuk...

To identify whether muscle metaboreceptor stimulation alters baroreflex control of muscle sympathetic nerve activity (MSNA), MSNA, beat-by-beat arterial blood pressure (Finapres), and electrocardiogram were recorded in 11 healthy subjects in the supine position. Subjects performed 2 min of isometric handgrip exercise at 40% of maximal voluntary contraction followed by 2.5 min of posthandgrip mu...

This work includes the development of two spectrophotometric methods which are sensitive, accurate, stable, and has good recovery for determination phenylephrine-HCl as free form in pharmaceutical preparations. In method (A), phenylephrine is oxidized by potassium permanganate a basic solution sodium hydroxide bluish-green color resulting manganate (MnO 42- ) measured at wavelength 610 nm, line...

The Au–Bi binary system electrodeposited on the surface of a glassy carbon electrode exhibits catalytic activity during electrooxidation phenylephrine, paracetamol, and caffeine that enhances peak currents decreases overvoltage in oxidation organic compounds. potential difference between peaks modified is 400 mV for phenylephrine paracetamol 300 caffeine, respectively. possibility simultaneous ...

To identify whether whole body heating alters arterial baroreflex control of muscle sympathetic nerve activity (MSNA), MSNA and beat-by-beat arterial blood pressure were recorded in seven healthy subjects during acute hypotensive and hypertensive stimuli in both normothermic and heat stress conditions. Whole body heating significantly increased sublingual temperature (P < 0.01), MSNA (P < 0.01)...

background: alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. in this study, we investigated the effect of sustained hypoxic ventilation o...