An increasing body of evidence supports the hypothesis that diminished function of N-methyl-D-aspartate (NMDA) receptors and the associated increase in glutamate release and overstimulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors are critical elements of the pathophysiology of schizophrenia. Here, we describe a halogenated derivative of the aromatic ...

The blood coagulation cascade includes a step in which the soluble protein, factor VIIa (fVIIa), complexes with its transmembrane receptor, tissue factor (TF). The fVIIa/TF protein-protein complex is subsequently drawn into the cell by endocytosis. The observation that TF is aberrantly and abundantly expressed on many cancer cells offers an opportunity to specifically target those cells with an...

Studies of the processes self-organization and self-assembly various complexly organized (including spiral) structures based on amino acids intensively carried out in recent years. Various methods molecular modeling, including dynamics (MD) methods, are developed. In this paper, we propose a new approach for relatively simple technique conducting MD simulation (MDS) nanostructures, determining ...

The solid-phase polymerization synthesis (SPPS) represents one of the most innovative approaches to preparation nano-sized molecularly imprinted polymers. One its main features consists use a solid support on which template molecule is covalently grafted. It implies that imprinting process does not involve target as is, but, rather, structural modification it. known rationally designed mimic N-...

Residual DBS specimens from newborns diagnosed with Phenylketonuria, Congenital Hypothyroidism, Cystic Fibrosis, Adrenal Hyperplasia and Galactosemia collected within 1995-2018, stored in cardboard boxes at ambient temperature uncontrolled conditions, were retested for phenylalanine (Phe), thyrotropin (TSH), immunoreactive trypsinogen (IRT), total galactose (TGal) 17-hydroxyprogesterone (17OHP)...

MPKU pregnancies, with or without dietary treatment to reduce maternal plasma phenylalanine (phe), show variable, increased non-physiologic levels, as the putative cause of fetal teratogenicity. Cerebral dysgenesis with clinical neonatal microcephaly and congenital heart disease indicates altered organ morphogenesis. Although there is not an established precise relationship between maternal phe...

Phenylketonuria (PKU) is an autosomal recessive disorder, which is characterized by severe mental retardation, microcephaly and seizures. The symptoms of this disease can be prevented if detected soon after birth. Therefore, blood Phenylalanine (Phe) measurement is essential for the early diagnosis, treatment and dietary monitoring of PKU patients. The goal of this research was to introduce a r...

A human inborn genetic disease, type I phenylketonuria [13] (PKU) is caused by a mutation in the gene encoding the enzyme phenylalanine dehydrogenase necessary to convert L-phenylalanine (L-Phe) to L-tyrosine, (L-Tyr). The accumulated L-Phe is metabolized by enforced side reaction to phenylpyruvate, phenylacetate, and phenyl-L-lactate excreted with urine, Fig. 1. The excess of phenylalanine hin...

The compounds benzyloxycarbonyl-L-leucyl-hydroxamate (Z-Leu-NHOH), phosphoryl-L-leucyl-L-phenylalanine (P-Leu-Phe) and 2-mercaptoacetyl-L-phenylalanyl-L-leucine (HSAc-Phe-Leu) strongly inhibit the activity of Pseudomonas elastase in vitro. The capacity of these inhibitors to prevent corneal melting and perforation due to the elastase was examined in rabbit eyes by intrastromal injections of ela...

OBJECTIVES To compare the neurocognitive outcomes of patients with phenylketonuria (PKU) to determine whether decreasing phenylalanine (Phe) levels to <240 is preferable to the use of 360 μmol/L as an upper-target Phe level. An additional aim was to establish the influence of biochemical indices other than Phe on neurocognitive outcomes. STUDY DESIGN Patients with PKU (n = 63; mean age 10.8 ±...