The role of the microcirculation is increasingly being recognized in the pathophysiology of cardiovascular disease. The microcirculation is a major site of damage in most target organs of cardiovascular disease, such as the heart, brain, and kidney. Both functional and structural alterations in the small arteries, arterioles, and capillaries are the basis of target organ damage. Furthermore, th...

The world population is growing rapidly. As a consequence increasingly more products of crop plants are needed. Here, plant breeding gains a special significance. The goal of plant breeding is to develop new cultivars that need less nutrients and at the same time are more resistent to diseases and pests. A deciding factor is the mapping from gene analysis to the phenotype of the plant, i.e., al...

Progress in molecular genetics has changed cardiovascular research. The mouse has turned out to be an invaluable model for mammalian genetic modifications to mimic and analyse cardiovascular pathology. Through the introduction of transgene and gene targeting technology, regulatory systems can be studied at the molecular level. Recent technical developments have down-sized the equipment for phys...