Abstract Cardiometabolic diseases (CMDs) are a major cause of mortality worldwide, yet men and women present remarkable differences in disease prognosis, onset manifestation. Here we characterize how sex cardiometabolic risk factors vary with age by examining 45 phenotypes 6 lifestyle 146,021 participants the Dutch population cohort Lifelines. We show that 71% studied phenotypes. For 31% these ...

Background: Phenotype similarity calculation should be used to help improve drug repurposing. In this study, based on the MeSH terms describing phenotypes deposited in OMIM, we proposed a method, namely, PheSom (Phenotype Similarity On MeSH), measure between phenotypes. counted number of overlapping two and then took weight every term within each phenotype into account according frequency-inver...

Macrophages’ role in the evolution of solid tumours is a well accepted fact, with M1-like macrophages having an anti-tumour and M2-like pro-tumour role. Despite fact that some clinical studies on lung have emphasised also presence mixed M1 M2 phenotypes addition to distinct phenotypes, majority still use M1-M2 classification predict patient survival. In this theoretical study we mathematical mo...